23S rRNK (guanin748-N1)-metiltransferaza
| 23S rRNK (guanin748-N1)-metiltransferaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 2.1.1.188 | ||||||||
| Baze podataka | |||||||||
| IntEnz | IntEnz pregled | ||||||||
| BRENDA | BRENDA pristup | ||||||||
| ExPASy | NiceZyme pregled | ||||||||
| KEGG | KEGG pristup | ||||||||
| MetaCyc | metabolički put | ||||||||
| PRIAM | profil | ||||||||
| Strukture PBP | RCSB PDB PDBe PDBj PDBsum | ||||||||
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23S rRNK (guanin748-N1)-metiltransferaza (EC 2.1.1.188, Rlma(II), Rlma2, 23S rRNK m1G748 metiltransferaza, RlmaII, Rlma II, metiltransferaza tilozinske otpornosti RlmA(II), TlrB, metiltransferaza II velike podjedinice rRNK) je enzim sa sistematskim imenom S-adenozil-L-metionin:23S rRNK (guanin748-N1)-metiltransferaza.[1][2][3][4][5][6] Ovaj enzim katalizuje sledeću hemijsku reakciju
- S-adenozil-L-metionin + guanin748 u 23S rRNK S-adenozil-L-homocistein + N1-metilguanin748 u 23S rRNK
Ovaj enzim specifično metiliše guanin748 u N1 poziciji 23S rRNK. Metiltransferaza RlmAII pruža otpornost na makrolidni antibiotik tilozin u otpornoj vrsti bakterije Streptomyces fradiae.
Reference
[уреди | уреди извор]- ^ Douthwaite, S., Crain, P.F., Liu, M. and Poehlsgaard, J. (2004). „The tylosin-resistance methyltransferase RlmAII (TlrB) modifies the N-1 position of 23S rRNA nucleotide G748”. J. Mol. Biol. 337: 1073—1077. PMID 15046978.
- ^ Liu, M., Kirpekar, F., Van Wezel, G.P. and Douthwaite, S. (2000). „The tylosin resistance gene tlrB of Streptomyces fradiae encodes a methyltransferase that targets G748 in 23S rRNA”. Mol. Microbiol. 37: 811—820. PMID 10972803.
- ^ Lebars, I., Yoshizawa, S., Stenholm, A.R., Guittet, E., Douthwaite, S. and Fourmy, D. (2003). „Structure of 23S rRNA hairpin 35 and its interaction with the tylosin-resistance methyltransferase RlmAII”. EMBO J. 22: 183—192. PMID 12514124.
- ^ Lebars, I., Husson, C., Yoshizawa, S., Douthwaite, S. and Fourmy, D. (2007). „Recognition elements in rRNA for the tylosin resistance methyltransferase RlmAII”. J. Mol. Biol. 372: 525—534. PMID 17673230.
- ^ Douthwaite, S., Jakobsen, L., Yoshizawa, S. and Fourmy, D. (2008). „Interaction of the tylosin-resistance methyltransferase RlmAII at its rRNA target differs from the orthologue RlmAI”. J. Mol. Biol. 378: 969—975. PMID 18406425.
- ^ Liu, M. & Douthwaite, S. (2002). „Methylation at nucleotide G745 or G748 in 23S rRNA distinguishes Gram-negative from Gram-positive bacteria”. Mol. Microbiol. 44: 195—204. PMID 11967079.
Literatura
[уреди | уреди извор]- Nicholas C. Price; Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third изд.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 изд.). Wiley-Interscience. ISBN 0471205036.
- Branden C; Tooze J. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 изд.). Wiley Classics Library. ISBN 0471303097.
- William P. Jencks (1987). Catalysis in Chemistry and Enzymology. Dover Publications. ISBN 0486654605.
Spoljašnje veze
[уреди | уреди извор]- 23S+rRNA+(guanine748-N1)-methyltransferase на US National Library of Medicine Medical Subject Headings (MeSH)
