4-Hidroksi-3-metilbut-2-en-1-il difosfat sintaza
| 4-hidroksi-3-metilbut-2-en-1-il difosfat sintaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 1.17.7.1 | ||||||||
| Baze podataka | |||||||||
| IntEnz | IntEnz pregled | ||||||||
| BRENDA | BRENDA pristup | ||||||||
| ExPASy | NiceZyme pregled | ||||||||
| KEGG | KEGG pristup | ||||||||
| MetaCyc | metabolički put | ||||||||
| PRIAM | profil | ||||||||
| Strukture PBP | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
4-hidroksi-3-metilbut-2-en-1-il difosfat sintaza (EC 1.17.7.1, 4-hidroksi-3-metilbut-2-en-1-il difosfatna sintaza, (E)-4-hidroksi-3-metilbut-2-en-1-il-difosfat:protein-disulfidna oksidoreduktaza (hidratacija), (E)-4-hidroksi-3-metilbut-2-enil difosfatna sintaza, GcpE) je enzim sa sistematskim imenom (E)-4-hidroksi-3-metilbut-2-en-1-il-difosfat:oksidovani feredoksin oksidoreduktaza.[1][2][3][4][5] Ovaj enzim katalizuje sledeću hemijsku reakciju
- (E)-4-hidroksi-3-metilbut-2-en-1-il difosfat + H2O + 2 oksidovani feredoksin 2-C-metil-D-eritritol 2,4-ciklodifosfat + 2 redukovani feredoksin
Ovaj enzim je gvožđe-sumporni protein koji sadrži [4Fe-4S] kluster. On deluje u reverznom smeru.
Reference
[уреди | уреди извор]- ^ Hecht, S., Eisenreich, W., Adam, P., Amslinger, S., Kis, K., Bacher, A., Arigoni, D. and Rohdich, F. (2001). „Studies on the nonmevalonate pathway to terpenes: the role of the GcpE (IspG) protein”. Proc. Natl. Acad. Sci. USA. 98: 14837—14842. PMID 11752431.
- ^ Okada, K. & Hase, T. (2005). „Cyanobacterial non-mevalonate pathway: (E)-4-hydroxy-3-methylbut-2-enyl diphosphate synthase interacts with ferredoxin in Thermosynechococcus elongatus BP-1”. J. Biol. Chem. 280: 20672—20679. PMID 15792953.
- ^ Seemann, M., Wegner, P., Schünemann, V., Tse Sum Bui, B., Wolff, M., Marquet, A., Trautwein, A.X. and Rohmer, M. (2005). „Isoprenoid biosynthesis in chloroplasts via the methylerythritol phosphate pathway: the (E)-4-hydroxy-3-methylbut-2-enyl diphosphate synthase (GcpE) from Arabidopsis thaliana is a [4Fe-4S] protein”. J. Biol. Inorg. Chem. 10: 131—137. PMID 15650872.
- ^ Seemann, M., Tse Sum Bui, B., Wolff, M., Tritsch, D., Campos, N., Boronat, A., Marquet, A. and Rohmer, M. (2002). „Isoprenoid biosynthesis through the methylerythritol phosphate pathway: the (E)-4-hydroxy-3-methylbut-2-enyl diphosphate synthase (GcpE) is a [4Fe-4S] protein”. Angew. Chem. Int. Ed. Engl. 41: 4337—4339. PMID 12434382.
- ^ Seemann, M., Tse Sum Bui, B., Wolff, M., Miginiac-Maslow, M. and Rohmer, M. (2006). „Isoprenoid biosynthesis in plant chloroplasts via the MEP pathway: direct thylakoid/ferredoxin-dependent photoreduction of GcpE/IspG”. FEBS Lett. 580: 1547—1552. PMID 16480720.
Literatura
[уреди | уреди извор]- Nicholas C. Price; Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third изд.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 изд.). Wiley-Interscience. ISBN 0471205036.
- Branden C; Tooze J. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 изд.). Wiley Classics Library. ISBN 0471303097.
Spoljašnje veze
[уреди | уреди извор]- 4-hydroxy-3-methylbut-2-enyl-diphosphate+synthase на US National Library of Medicine Medical Subject Headings (MeSH)
