8-Fenilteofilin

8-Fenilteofilin
IUPAC ime
	8-fenil-1,3-dimetil-7H-purin-2,6-dion
Identifikatori
CAS broj	961-45-5
ATC kod	none
PubChem	CID 1922
ChemSpider	1846
ChEMBL	CHEMBL62350
Hemijski podaci
Formula	C13H12N4O2
Molarna masa	256,259 g/mol
	SMILES c3ccccc3-c(nc12)nc2n(C)c(=O)n(C)c1=O; ;
	InChI InChI=1S/C13H12N4O2/c1-16-11-9(12(18)17(2)13(16)19)14-10(15-11)8-6-4-3-5-7-8/h3-7H,1-2H3,(H,14,15) ; Key:PJFMAVHETLRJHJ-UHFFFAOYSA-N ;

8-Fenilteofilin (8-fenil-1,3-dimetilksantin, 8-PT) je lek iz ksantinske familije koji deluje kao potentan i selektivan antagonist adenozinskih receptora A₁ i A_2A, ali za razliku od drugih derivata ksantina on nije inhibitor fosfodiesteraze.^[1]^[2]^[3] On ima stimulantno dejstvo u životinjskim studijama i sličnu potentnost sa kofeinom.^[4] 8-Fenilteofilin je isto tako potentan i selektivan inhibitor jetrenog enzima CYP1A2 zbog čeka je verovatno da uzrokuje nepoželjne interakcije sa drugim lekovima koje CYP1A2 normalno metaboliše.^[5]

Reference

^ Scotini E, Carpenedo F, Fassina G (1983). „New derivatives of methyl-xanthines: effect of thiocaffeine thiotheophylline and 8-phenyltheophylline on lipolysis and on phosphodiesterase activities”. Pharmacological Research Communications. 15 (2): 131—43. PMID 6844374.
^ Rabe KF, Magnussen H, Dent G (1995). „Theophylline and selective PDE inhibitors as bronchodilators and smooth muscle relaxants”. The European Respiratory Journal : Official Journal of the European Society for Clinical Respiratory Physiology. 8 (4): 637—42. PMID 7664866.
^ Howell LL, Morse WH, Spealman RD (1990). „Respiratory effects of xanthines and adenosine analogs in rhesus monkeys”. The Journal of Pharmacology and Experimental Therapeutics. 254 (3): 786—91. PMID 2395111.
^ Spealman RD (1988). „Psychomotor stimulant effects of methylxanthines in squirrel monkeys: relation to adenosine antagonism”. Psychopharmacology. 95 (1): 19—24. PMID 3133696.
^ Murray S, Odupitan AO, Murray BP, Boobis AR, Edwards RJ (2001). „Inhibition of human CYP1A2 activity in vitro by methylxanthines: potent competitive inhibition by 8-phenyltheophylline”. Xenobiotica. 31 (3): 135—51. PMID 11465391. doi:10.1080/00498250110043292.

Vidi još

[pmid6844374-1] Scotini E, Carpenedo F, Fassina G (1983). „New derivatives of methyl-xanthines: effect of thiocaffeine thiotheophylline and 8-phenyltheophylline on lipolysis and on phosphodiesterase activities”. Pharmacological Research Communications. 15 (2): 131—43. PMID 6844374.

[pmid7664866-2] Rabe KF, Magnussen H, Dent G (1995). „Theophylline and selective PDE inhibitors as bronchodilators and smooth muscle relaxants”. The European Respiratory Journal : Official Journal of the European Society for Clinical Respiratory Physiology. 8 (4): 637—42. PMID 7664866.

[pmid2395111-3] Howell LL, Morse WH, Spealman RD (1990). „Respiratory effects of xanthines and adenosine analogs in rhesus monkeys”. The Journal of Pharmacology and Experimental Therapeutics. 254 (3): 786—91. PMID 2395111.

[pmid3133696-4] Spealman RD (1988). „Psychomotor stimulant effects of methylxanthines in squirrel monkeys: relation to adenosine antagonism”. Psychopharmacology. 95 (1): 19—24. PMID 3133696.

[pmid11465391-5] Murray S, Odupitan AO, Murray BP, Boobis AR, Edwards RJ (2001). „Inhibition of human CYP1A2 activity in vitro by methylxanthines: potent competitive inhibition by 8-phenyltheophylline”. Xenobiotica. 31 (3): 135—51. PMID 11465391. doi:10.1080/00498250110043292.

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