A-1,6-manozil-glikoprotein 4-b-N-acetilglukozaminiltransferaza
| A-1,6-manozil-glikoprotein 4-b-N-acetilglukozaminiltransferaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 2.4.1.201 | ||||||||
| CAS broj | 119699-68-2 | ||||||||
| Baze podataka | |||||||||
| IntEnz | IntEnz pregled | ||||||||
| BRENDA | BRENDA pristup | ||||||||
| ExPASy | NiceZyme pregled | ||||||||
| KEGG | KEGG pristup | ||||||||
| MetaCyc | metabolički put | ||||||||
| PRIAM | profil | ||||||||
| Strukture PBP | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
A-1,6-manozil-glikoprotein 4-b-N-acetilglukozaminiltransferaza (EC 2.4.1.201, N-acetilglukozaminiltransferaza VI, N-glikozil-oligosaharid-glikoprotein N-acetilglukozaminiltransferaza VI, uridin difosfoacetilglukozamin-glikopeptid beta-1->4-acetilglukozaminiltransferaza VI, manozil-glikoprotein beta-1,4-N-acetilglukozaminiltransferaza, GnTVI) je enzim sa sistematskim imenom UDP-N-acetil-D-glukozamin:2,6-bis(N-acetil-beta-D-glukozaminil)-alfa-D-manozil-glikoprotein 4-beta-N-acetil-D-glukozaminiltransferaza.[1][2] Ovaj enzim katalizuje sledeću hemijsku reakciju
- UDP-N-acetil-D-glukozamin + 2,6-bis(N-acetil-beta-D-glukozaminil)-alfa-D-manozil-R UDP + 2,4,6-tris(N-acetil-beta-D-glukozaminil)-alfa-D-manozil-R
R označava ostatak N-vezanog oligosaharida u glikoproteinskom akceptoru.
Reference
[уреди | уреди извор]- ^ Brockhausen, I., Hull, E., Hindsgaul, O., Schachter, H., Shah, R.N., Michnick, S.W. and Carver, J.P. (1989). „Control of glycoprotein synthesis. Detection and characterization of a novel branching enzyme from hen oviduct, UDP-N-acetylglucosamine:GlcNAc β1-6 (GlcNAc β1-2)Man α-R (GlcNAc to Man) β-4-N-acetylglucosaminyltransferase VI”. J. Biol. Chem. 264: 11211—11221. PMID 2525556.
- ^ Taguchi, T., Ogawa, T., Inoue, S., Inoue, Y., Sakamoto, Y., Korekane, H. and Taniguchi, N. (2000). „Purification and characterization of UDP-GlcNAc:GlcNAcβ1-6(GlcNAcβ1-2)Manα1-R [GlcNAc to Man]-β1,4-N-acetylglucosaminyltransferase VI from hen oviduct”. J. Biol. Chem. 275: 32598—32602. PMID 10903319.
Literatura
[уреди | уреди извор]- Nicholas C. Price; Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third изд.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 изд.). Wiley-Interscience. ISBN 0471205036.
- Branden C; Tooze J. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 изд.). Wiley Classics Library. ISBN 0471303097.
- William P. Jencks (1987). Catalysis in Chemistry and Enzymology. Dover Publications. ISBN 0486654605.
Spoljašnje veze
[уреди | уреди извор]- Alpha-1,6-mannosyl-glycoprotein+4-beta-N-acetylglucosaminyltransferase на US National Library of Medicine Medical Subject Headings (MeSH)
