ADAMTS-4 endopeptidaza
| ADAMTS-4 endopeptidaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 3.4.24.82 | ||||||||
| CAS broj | 147172-61-0 | ||||||||
| Baze podataka | |||||||||
| IntEnz | IntEnz pregled | ||||||||
| BRENDA | BRENDA pristup | ||||||||
| ExPASy | NiceZyme pregled | ||||||||
| KEGG | KEGG pristup | ||||||||
| MetaCyc | metabolički put | ||||||||
| PRIAM | profil | ||||||||
| Strukture PBP | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
ADAMTS-4 endopeptidaza (EC 3.4.24.82, agrekanaza-1) je enzim.[1] Ovaj enzim katalizuje sledeću hemijsku reakciju
- Glutamilna endopeptidaza. Razlaže vezu -Thr-Glu-Gly-Glu373-Ala-Arg-Gly-Ser- u interglobularnom domenu agrekana sisara
Ovaj enzim pripada peptidaznoj familiji M12.
Reference
[уреди | уреди извор]- ^ Westling, J., Fosang, A.J., Last, K., Thompson, V.P., Tomkinson, K.N., Hebert, T., McDonagh, T., Collins-Racie, L.A., LaVallie, E.R., Morris, E.A. and Sandy, J.D. (2002). „ADAMTS4 cleaves at the aggrecanase site (Glu373-Ala374) and secondarily at the matrix metalloproteinase site (Asn341-Phe342) in the aggrecan interglobular domain”. J. Biol. Chem. 277: 16059—16066. PMID 11854269.
Literatura
[уреди | уреди извор]- Nicholas C. Price; Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third изд.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 изд.). Wiley-Interscience. ISBN 0471205036.
- Branden C; Tooze J. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 изд.). Wiley Classics Library. ISBN 0471303097.
Spoljašnje veze
[уреди | уреди извор]- ADAMTS-4+endopeptidase на US National Library of Medicine Medical Subject Headings (MeSH)
