beta-alanin

β-alanin
Nazivi
	IUPAC naziv 3-aminopropionska kiselina
	Drugi nazivi β-alanin; 3-Aminopropionska kiselina
Identifikacija
CAS broj	107-95-9 ;
3D model (Jmol)	interaktivna slika;
ChEBI	CHEBI:16958 ;
ChemSpider	234 ;
DrugBank	DB03107 ;
ECHA InfoCard	100.003.215
IUPHAR/BPS	2365;
KEGG	D07561 ;
PubChem C ID	239;
UNII	11P2JDE17B ;
	SMILES O=C(O)CCN; ; ; ; ; ;
Svojstva
Hemijska formula	C3H7NO2
Molarna masa	89,093 g/mol
Agregatno stanje	Bipirimidalni kristali
Gustina	1,437 g/cm³ (19 °C)
Tačka topljenja	207 °C razlaže se.
Rastvorljivost u vodi	rastvoran je
	Ukoliko nije drugačije napomenuto, podaci se odnose na standardno stanje materijala (na 25 °C [77 °F], 100 kPa).
	verifikuj (šta je ?)
	Reference infokutije

β-alanin (ili beta-alanin) je prirodna beta aminokiselina. Njena aminogrupa je u β-poziciji u odnosu na karboksilatnu grupu (tj. udaljena je dva atoma). IUPAC ime za β-alanin je 3-aminopropionska kiselina. Za razliku od α-alanina, β-alanin nema stereocentar.

β-alanin se ne koristi u biosintezi glavnih proteina ili enzima. On se formira in vivo degradacijom dihidrouracila i karnozina. On je komponenta prirodnih peptida karnozina i anserina, kao i pantotenske kiseline (vitamina B₅), koja je komponenta koenzima A. Pod normalnim okolnostima, β-alanin se metaboliše do sirćetne kiseline.

β-alanin je prekurzor karnozina, i stoga su nivoi karnozina su ograničeni količinom dostupnog β-alanina. Suplementacija β-alaninom dovodi do povišenja koncentracije karnozina u mišićima, umanjenja zamora kod atletičara i uvećanja radne sposobnosti mišića.^[6]^[7]

Reference

^ Joanne Wixon; Douglas Kell (2000). „Website Review: The Kyoto Encyclopedia of Genes and Genomes — KEGG”. Yeast. 17 (1): 48—55. doi:10.1002/(SICI)1097-0061(200004)17:1<48::AID-YEA2>3.0.CO;2-H.
^ Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today. 15 (23-24): 1052—7. PMID 20970519. doi:10.1016/j.drudis.2010.10.003. уреди
^ Evan E. Bolton; Yanli Wang; Paul A. Thiessen; Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry. 4: 217—241. doi:10.1016/S1574-1400(08)00012-1.
^ The Merck Index: An Encyclopedia of Chemicals, Drugs, and Biologicals (11th изд.). Merck Publishing. 1989. ISBN 091191028X. , 196 </noinclude>.
^ Weast, Robert C., ур. (1981). CRC Handbook of Chemistry and Physics (62nd изд.). Boca Raton, FL: CRC Press. ISBN 0-8493-0462-8. .
^ Derave W, Ozdemir MS, Harris R, Pottier A, Reyngoudt H, Koppo K, Wise JA, Achten E (9. 8. 2007). „Beta-alanine supplementation augments muscle carnosine content and attenuates fatigue during repeated isokinetic contraction bouts in trained sprinters”. J Appl Physiol. 103 (5): 1736. PMID 17690198. doi:10.1152/japplphysiol.00397.2007.
^ Hill CA, Harris RC, Kim HJ, Harris BD, Sale C, Boobis LH, Kim CK, Wise JA (2007). „Influence of beta-alanine supplementation on skeletal muscle carnosine concentrations and high intensity cycling capacity”. Amino Acids. 32 (2): 225—33. PMID 16868650. doi:10.1007/s00726-006-0364-4.

Spoljašnje veze

KEGG map of β-alanine metabolism Архивирано на сајту Wayback Machine (2. март 2009)

[1] Joanne Wixon; Douglas Kell (2000). „Website Review: The Kyoto Encyclopedia of Genes and Genomes — KEGG”. Yeast. 17 (1): 48—55. doi:10.1002/(SICI)1097-0061(200004)17:1<48::AID-YEA2>3.0.CO;2-H.

[2] Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today. 15 (23-24): 1052—7. PMID 20970519. doi:10.1016/j.drudis.2010.10.003. уреди

[3] Evan E. Bolton; Yanli Wang; Paul A. Thiessen; Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry. 4: 217—241. doi:10.1016/S1574-1400(08)00012-1.

[4] The Merck Index: An Encyclopedia of Chemicals, Drugs, and Biologicals (11th изд.). Merck Publishing. 1989. ISBN 091191028X. , 196 </noinclude>.

[5] Weast, Robert C., ур. (1981). CRC Handbook of Chemistry and Physics (62nd изд.). Boca Raton, FL: CRC Press. ISBN 0-8493-0462-8. .

[6] Derave W, Ozdemir MS, Harris R, Pottier A, Reyngoudt H, Koppo K, Wise JA, Achten E (9. 8. 2007). „Beta-alanine supplementation augments muscle carnosine content and attenuates fatigue during repeated isokinetic contraction bouts in trained sprinters”. J Appl Physiol. 103 (5): 1736. PMID 17690198. doi:10.1152/japplphysiol.00397.2007.

[Hill2007-7] Hill CA, Harris RC, Kim HJ, Harris BD, Sale C, Boobis LH, Kim CK, Wise JA (2007). „Influence of beta-alanine supplementation on skeletal muscle carnosine concentrations and high intensity cycling capacity”. Amino Acids. 32 (2): 225—33. PMID 16868650. doi:10.1007/s00726-006-0364-4.

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