CXCL7

Pro-trombocit bazični protein (hemokin (C-X-C motiv) ligand 7)
Pro-trombocit bazični protein (hemokin (C-X-C motiv) ligand 7)
	PDB prikaz baziran na 1f9p.
Dostupne strukture
	1f9p, 1nap, 1tvx
Identifikatori
Simboli	PPBP; PBP; B-TG1; Beta-TG; CTAP-III; CTAP3; CTAPIII; CXCL7; LA-PF4; LDGF; MDGF; NAP-2; SCYB7; TC1; TC2; TGB; TGB1; THBGB; THBGB1
Vanjski ID	OMIM: 121010 MGI: 1888712 HomoloGene: 48122 GeneCards: PPBP Gene
Ontologija gena
Molekularna funkcija	• aktivnost glukoznog transmembranskog transportera; • hemokinska altivnost; • aktivnost faktora rasta;
Celularna komponenta	• ekstracelularni region; • ekstracelularni prostor;
Biološki proces	• regulacija progresije kroz ćelijski ciklus; • hemotaksa; • imunski odgovor; • ćelijska proliferacija; • glukozni transport; • odbrambeni respons na bakterije;
Pregled RNK izražavanja
	podaci
Ortolozi
Vrsta	Čovek
Entrez	5473
Ensembl	ENSG00000163736
UniProt	P02775
RefSeq (mRNA)	NM_002704
RefSeq (protein)	NP_002695
Lokacija (UCSC)	Chr 4:; 75.07 - 75.07 Mb
PubMed pretraga	[1]

CXCL7, hemokin (C-X-C motiv) ligand 7, je ljudski gen^[1] koji kodira istoimeni protein. CXCL7 je mali citokin iz CXC hemokin familije. On je izoforma beta-tromboglobulina ili protrombocit bazični protein (PPBP).^[2]^[3]

CXCL7 protein se oslobađa u velikim količinama iz trombocita nakon njihove aktivacije.^[4] On stimuliše razne procese uključujući mitogenezu, sintezu ekstracelularnog matriksa, metabolizam glukoze i sintezu plazminogen aktivatora.^[5]^[6]

Reference

^ „Entrez Gene: PPBP pro-platelet basic protein (chemokine (C-X-C motif) ligand 7)”.
^ Hristov M; Zernecke A; Bidzhekov K; et al. (2007). „Importance of CXC chemokine receptor 2 in the homing of human peripheral blood endothelial progenitor cells to sites of arterial injury”. Circ. Res. 100 (4): 590—7. PMID 17272812. doi:10.1161/01.RES.0000259043.42571.68.
^ Mire-Sluis, Anthony R.; Thorpe, Robin, ур. (1998). Cytokines (Handbook of Immunopharmacology). Boston: Academic Press. ISBN 0-12-498340-5.
^ Majumdar S, Gonder D, Koutsis B, Poncz M (1991). „Characterization of the human beta-thromboglobulin gene. Comparison with the gene for platelet factor 4”. J Biol Chem. 266 (9): 5785—9. PMID 1826003.
^ Castor C, Miller J, Walz D (1983). „Structural and biological characteristics of connective tissue activating peptide (CTAP-III), a major human platelet-derived growth factor”. Proc Natl Acad Sci USA. 80 (3): 765—9. PMC 393460 . PMID 6572368. doi:10.1073/pnas.80.3.765.
^ Castor C, Furlong A, Carter-Su C (1985). „Connective tissue activation: stimulation of glucose transport by connective tissue activating peptide III”. Biochemistry. 24 (7): 1762—7. PMID 4005226. doi:10.1021/bi00328a029.

Literatura

Begg GS, Pepper DS, Chesterman CN, Morgan FJ (1978). „Complete covalent structure of human beta-thromboglobulin.”. Biochemistry. 17 (9): 1739—44. PMID 77677. doi:10.1021/bi00602a024.
Kaplan KL; Broekman MJ; Chernoff A; et al. (1979). „Platelet alpha-granule proteins: studies on release and subcellular localization.”. Blood. 53 (4): 604—18. PMID 426909.
Tunnacliffe A, Majumdar S, Yan B, Poncz M (1992). „Genes for beta-thromboglobulin and platelet factor 4 are closely linked and form part of a cluster of related genes on chromosome 4.”. Blood. 79 (11): 2896—900. PMID 1316786.
Cohen AB; Stevens MD; Miller EJ; et al. (1992). „Generation of the neutrophil-activating peptide-2 by cathepsin G and cathepsin G-treated human platelets.”. Am. J. Physiol. 263 (2 Pt 1): L249—56. PMID 1387511.
Morris SW; Nelson N; Valentine MB; et al. (1992). „Assignment of the genes encoding human interleukin-8 receptor types 1 and 2 and an interleukin-8 receptor pseudogene to chromosome 2q35.”. Genomics. 14 (3): 685—91. PMID 1427896. doi:10.1016/S0888-7543(05)80169-7.
Majumdar S, Gonder D, Koutsis B, Poncz M (1991). „Characterization of the human beta-thromboglobulin gene. Comparison with the gene for platelet factor 4.”. J. Biol. Chem. 266 (9): 5785—9. PMID 1826003.
Wenger RH, Hameister H, Clemetson KJ (1991). „Human platelet basic protein/connective tissue activating peptide-III maps in a gene cluster on chromosome 4q12-q13 along with other genes of the beta-thromboglobulin superfamily.”. Hum. Genet. 87 (3): 367—8. PMID 1830861. doi:10.1007/BF00200921.
Hjemdahl P; Perneby C; Theodorsson E; et al. (1992). „A new assay for beta-thromboglobulin in urine.”. Thromb. Res. 64 (1): 33—43. PMID 1837963. doi:10.1016/0049-3848(91)90203-9.
Brandt E, Van Damme J, Flad HD (1991). „Neutrophils can generate their activator neutrophil-activating peptide 2 by proteolytic cleavage of platelet-derived connective tissue-activating peptide III.”. Cytokine. 3 (4): 311—21. PMID 1873479. doi:10.1016/1043-4666(91)90499-4.
Clark-Lewis I; Moser B; Walz A; et al. (1991). „Chemical synthesis, purification, and characterization of two inflammatory proteins, neutrophil activating peptide 1 (interleukin-8) and neutrophil activating peptide.”. Biochemistry. 30 (12): 3128—35. PMID 2007144. doi:10.1021/bi00226a021.
Walz A, Baggiolini M (1990). „Generation of the neutrophil-activating peptide NAP-2 from platelet basic protein or connective tissue-activating peptide III through monocyte proteases.”. J. Exp. Med. 171 (2): 449—54. PMC 2187709 . PMID 2406364. doi:10.1084/jem.171.2.449.
Holt JC; Harris ME; Holt AM; et al. (1986). „Characterization of human platelet basic protein, a precursor form of low-affinity platelet factor 4 and beta-thromboglobulin.”. Biochemistry. 25 (8): 1988—96. PMID 2423119. doi:10.1021/bi00356a023.
Walz A, Baggiolini M (1989). „A novel cleavage product of beta-thromboglobulin formed in cultures of stimulated mononuclear cells activates human neutrophils.”. Biochem. Biophys. Res. Commun. 159 (3): 969—75. PMID 2522778. doi:10.1016/0006-291X(89)92203-1.
Wenger RH; Wicki AN; Walz A; et al. (1989). „Cloning of cDNA coding for connective tissue activating peptide III from a human platelet-derived lambda gt11 expression library.”. Blood. 73 (6): 1498—503. PMID 2713489.
Castor CW; Walz DA; Ragsdale CG; et al. (1989). „Connective tissue activation. XXXIII. Biologically active cleavage products of CTAP-III from human platelets.”. Biochem. Biophys. Res. Commun. 163 (2): 1071—8. PMID 2783111. doi:10.1016/0006-291X(89)92330-9.
Holt JC; Rabellino EM; Gewirtz AM; et al. (1988). „Occurrence of platelet basic protein, a precursor of low affinity platelet factor 4 and beta-thromboglobulin, in human platelets and megakaryocytes.”. Exp. Hematol. 16 (4): 302—6. PMID 2966071.
Castor CW, Furlong AM, Carter-Su C (1985). „Connective tissue activation: stimulation of glucose transport by connective tissue activating peptide III.”. Biochemistry. 24 (7): 1762—7. PMID 4005226. doi:10.1021/bi00328a029.
McLaren KM, Pepper DS (1983). „Immunological localisation of beta-thromboglobulin and platelet factor 4 in human megakaryocytes and platelets.”. J. Clin. Pathol. 35 (11): 1227—31. PMC 497932 . PMID 6183294. doi:10.1136/jcp.35.11.1227.
Castor CW, Miller JW, Walz DA (1983). „Structural and biological characteristics of connective tissue activating peptide (CTAP-III), a major human platelet-derived growth factor.”. Proc. Natl. Acad. Sci. U.S.A. 80 (3): 765—9. PMC 393460 . PMID 6572368. doi:10.1073/pnas.80.3.765.
Malkowski MG; Wu JY; Lazar JB; et al. (1995). „The crystal structure of recombinant human neutrophil-activating peptide-2 (M6L) at 1.9-A resolution.”. J. Biol. Chem. 270 (13): 7077—87. PMID 7706245. doi:10.1074/jbc.270.13.7077.

Spoljašnje veze

Platelet+factor+7 на US National Library of Medicine Medical Subject Headings (MeSH)

[entrez-1] „Entrez Gene: PPBP pro-platelet basic protein (chemokine (C-X-C motif) ligand 7)”.

[2] Hristov M; Zernecke A; Bidzhekov K; et al. (2007). „Importance of CXC chemokine receptor 2 in the homing of human peripheral blood endothelial progenitor cells to sites of arterial injury”. Circ. Res. 100 (4): 590—7. PMID 17272812. doi:10.1161/01.RES.0000259043.42571.68.

[3] Mire-Sluis, Anthony R.; Thorpe, Robin, ур. (1998). Cytokines (Handbook of Immunopharmacology). Boston: Academic Press. ISBN 0-12-498340-5.

[4] Majumdar S, Gonder D, Koutsis B, Poncz M (1991). „Characterization of the human beta-thromboglobulin gene. Comparison with the gene for platelet factor 4”. J Biol Chem. 266 (9): 5785—9. PMID 1826003.

[5] Castor C, Miller J, Walz D (1983). „Structural and biological characteristics of connective tissue activating peptide (CTAP-III), a major human platelet-derived growth factor”. Proc Natl Acad Sci USA. 80 (3): 765—9. PMC 393460 . PMID 6572368. doi:10.1073/pnas.80.3.765.

[6] Castor C, Furlong A, Carter-Su C (1985). „Connective tissue activation: stimulation of glucose transport by connective tissue activating peptide III”. Biochemistry. 24 (7): 1762—7. PMID 4005226. doi:10.1021/bi00328a029.

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