Citohrom P450, familija 1, član A1
Citohrom P450, familija 1, član A1 je protein[1] koji je kod ljudi kodiran CYP1A1 genom.[2] Ovaj protein je član citohrom P450 superfamilije enzima.[3]
Funkcija
[уреди | уреди извор]CYP1A1 učestvuje u fazi I ksenobiotičkog metabolizma. Jedan od njegovih supstrata je teofilin. Inhibitori ovog enzima su fluorohinoloni i makrolidi. On se može indukovati aromatičnim ugljovodonicima.[4]
Reference
[уреди | уреди извор]- ^ Kawajiri K (1999). „CYP1A1”. IARC Scientific Publications (148): 159—72. PMID 10493257.
- ^ Nelson DR, Zeldin DC, Hoffman SM, Maltais LJ, Wain HM, Nebert DW (2004). „Comparison of cytochrome P450 (CYP) genes from the mouse and human genomes, including nomenclature recommendations for genes, pseudogenes and alternative-splice variants”. Pharmacogenetics. 14 (1): 1—18. PMID 15128046. doi:10.1097/00008571-200401000-00001.
- ^ Smith G, Stubbins MJ, Harries LW, Wolf CR (1998). „Molecular genetics of the human cytochrome P450 monooxygenase superfamily”. Xenobiotica. 28 (12): 1129—65. PMID 9890157. doi:10.1080/004982598238868.
- ^ Beresford AP (1993). „CYP1A1: friend or foe?”. Drug Metabolism Reviews. 25 (4): 503—17. PMID 8313840. doi:10.3109/03602539308993984.
Literatura
[уреди | уреди извор]- Nelson DR; Zeldin DC; Hoffman SM; et al. (2004). „Comparison of cytochrome P450 (CYP) genes from the mouse and human genomes, including nomenclature recommendations for genes, pseudogenes and alternative-splice variants.”. Pharmacogenetics. 14 (1): 1—18. PMID 15128046. doi:10.1097/00008571-200401000-00001.
- Masson LF, Sharp L, Cotton SC, Little J (2005). „Cytochrome P-450 1A1 gene polymorphisms and risk of breast cancer: a HuGE review.”. American Journal of Epidemiology. 161 (10): 901—15. PMID 15870154. doi:10.1093/aje/kwi121.
- Hildebrandt AG; Schwarz D; Krusekopf S; et al. (2007). „Recalling P446. P4501A1 (CYP1A1) opting for clinical application.”. Drug Metabolism Reviews. 39 (2-3): 323—41. PMID 17786624. doi:10.1080/03602530701498026.
- Nicholas C. Price; Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third изд.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 изд.). Wiley-Interscience. ISBN 0471205036.
- Branden C; Tooze J. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 изд.). Wiley Classics Library. ISBN 0471303097.
