Peptidaza mitohondrijalna prerade
| Peptidaza mitohondrijalna prerade | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 3.4.24.64 | ||||||||
| CAS broj | 86280-61-7 | ||||||||
| Baze podataka | |||||||||
| IntEnz | IntEnz pregled | ||||||||
| BRENDA | BRENDA pristup | ||||||||
| ExPASy | NiceZyme pregled | ||||||||
| KEGG | KEGG pristup | ||||||||
| MetaCyc | metabolički put | ||||||||
| PRIAM | profil | ||||||||
| Strukture PBP | RCSB PDB PDBe PDBj PDBsum | ||||||||
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Peptidaza mitohondrijalna prerade (EC 3.4.24.64, proteinaza transofmacije mitohondrijskog proteinskog prekurzora, matriks peptidaza, matriks procesujuća peptidaza, matriks procesujuća proteinaza, proteinaza transformacije mitohondrijskog proteinskog prekurzora, MPP) je enzim.[1][2][3][4][5] Ovaj enzim katalizuje sledeću hemijsku reakciju
- Oslobađanje N-terminalnog ciljnih peptida sa prekurzornih proteina unesenih u mitohondrion, tipično sa Arg u poziciji P2
Ovaj enzim je prisutan u mitohondrijskom matriksu gljiva i sisara.
Reference
[уреди | уреди извор]- ^ Jensen, R.E. & Yaffe, M.P. (1988). „Import of proteins into yeast mitochondria: the nuclear MAS2 gene encodes a component of the processing protease that is homologous to the MAS1-encoded subunit”. EMBO J. 7: 3863—3871. PMID 3061808.
- ^ Witte, C., Jensen, R.E., Yaffe, M.P. and Schatz, G. (1988). „MAS1, a gene essential for yeast mitochondrial assembly, encodes a subunit of the mitochondrial processing protease”. EMBO J. 7: 1439—1447. PMID 3044780.
- ^ Rawlings, N.D. & Barrett, A.J. (1991). „Homologues of insulinase, a new superfamily of metalloendopeptidases”. Biochem. J. 275: 389—391. PMID 2025223.
- ^ Kalousek, F., Neupert, W., Omura, T., Schatz, G. and Schmitz, U.K. (1993). „Uniform nomenclature for the mitochondrial peptidases cleaving precursors of mitochondrial proteins”. Trends Biochem. Sci. 18: 249—249. PMID 8212133.
- ^ Brunner, M. & Neupert, W. (1994). „Purification and characterization of the mitochondrial processing peptidase of Neurospora crassa”. Methods Enzymol. 248: 717—728.
Literatura
[уреди | уреди извор]- Nicholas C. Price; Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third изд.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 изд.). Wiley-Interscience. ISBN 0471205036.
- Branden C; Tooze J. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 изд.). Wiley Classics Library. ISBN 0471303097.
Spoljašnje veze
[уреди | уреди извор]- Mitochondrial+processing+peptidase на US National Library of Medicine Medical Subject Headings (MeSH)
