Ribonukleozid-trifosfat reduktaza
| Ribonukleozid-trifosfat reduktaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
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| Identifikatori | |||||||||
| EC broj | 1.17.4.2 | ||||||||
| CAS broj | 9068-66-0 | ||||||||
| Baze podataka | |||||||||
| IntEnz | IntEnz pregled | ||||||||
| BRENDA | BRENDA pristup | ||||||||
| ExPASy | NiceZyme pregled | ||||||||
| KEGG | KEGG pristup | ||||||||
| MetaCyc | metabolički put | ||||||||
| PRIAM | profil | ||||||||
| Strukture PBP | RCSB PDB PDBe PDBj PDBsum | ||||||||
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Ribonukleozid-trifosfat reduktaza (EC 1.17.4.2, ribonukleotidna reduktaza, 2'-dezoksiribonukleozid-trifosfat:oksidovani-tioredoksin 2'-oksidoreduktaza) je enzim sa sistematskim imenom 2'-dezoksiribonukleozid-trifosfat:tioredoksin-disulfid 2'-oksidoreduktaza.[1][2][3] Ovaj enzim katalizuje sledeću hemijsku reakciju:
- 2'-dezoksiribonukleozid trifosfat + tioredoksin disulfid + H2O ribonukleozid trifosfat + tioredoksin
Za rad ovog enzima je neophodan kobamidni koenzim i ATP.
Reference
[уреди | уреди извор]- ^ Blakley, R.L. (1965). „Cobamides and ribonucleotide reduction. I. Cobamide stimulation of ribonucleotide reduction in extracts of Lactobacillus leichmannii”. J. Biol. Chem. 240: 2173—2180. PMID 14299643.
- ^ Goulian, M. & Beck, W.S. (1966). „Purification and properties of cobamide-dependent ribonucleotide reductase from Lactobacillus leichmannii”. J. Biol. Chem. 241: 4233—4242. PMID 5924645.
- ^ Lammers, M. & Follmann, H. (1983). „The ribonucleotide reductases - a unique group of metalloenzymes essential for cell-proliferation”. Struct. Bonding. 54: 27—91.
Literatura
[уреди | уреди извор]- Nicholas C. Price; Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third изд.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 изд.). Wiley-Interscience. ISBN 0471205036.
- Branden C; Tooze J. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 изд.). Wiley Classics Library. ISBN 0471303097.
- William P. Jencks (1987). Catalysis in Chemistry and Enzymology. Dover Publications. ISBN 0486654605.
Spoljašnje veze
[уреди | уреди извор]- Ribonucleoside-triphosphate+reductase на US National Library of Medicine Medical Subject Headings (MeSH)
