Suksametonijum hlorid

Suksametonijum hlorid
IUPAC ime
	trimetil[2-({4-okso-4-[2-(trimetilazanijumil)etoksi]butanoil}oksi)etil]azanijum
Klinički podaci
Prodajno ime	Anectine, Quelicin, Sucostrin
Drugs.com	chloride.html Monografija
Način primene	Intravenozno
Farmakokinetički podaci
Izlučivanje	10% urinom
Identifikatori
CAS broj	306-40-1
ATC kod	M03AB01 (WHO)
PubChem	CID 5314
IUPHAR/BPS	4004
DrugBank	DB00202
ChemSpider	5123
KEGG	C07546
ChEMBL	CHEMBL45652
Hemijski podaci
Formula	C14H30N2O4
Molarna masa	290.399
	SMILES C[N+](C)(C)CCOC(=O)CCC(=O)OCC[N+](C)(C)C; ;
	InChI InChI=1S/C14H30N2O4/c1-15(2,3)9-11-19-13(17)7-8-14(18)20-12-10-16(4,5)6/h7-12H2,1-6H3/q+2 ; Key:AXOIZCJOOAYSMI-UHFFFAOYSA-N ;

Suksametonijum hlorid je kvaternarni relaksant skeletalnih mišića koji se koristi u obliku bromida, hlorida, ili jodida. On je depolarizacioni relaksant, koji deluje nakon oko 30 sekundi i čije dejstvo traje u proseku tri do pet minuta.^[1]^[2]^[3]

Reference

^ Jonsson M, Dabrowski M, Gurley DA, Larsson O, Johnson EC, Fredholm BB, Eriksson LI: Activation and inhibition of human muscular and neuronal nicotinic acetylcholine receptors by succinylcholine. Anesthesiology. 2006 Apr;104(4):724-33. PMID 16571968
^ Knox C, Law V, Jewison T, Liu P, Ly S, Frolkis A, Pon A, Banco K, Mak C, Neveu V, Djoumbou Y, Eisner R, Guo AC, Wishart DS (2011). „DrugBank 3.0: a comprehensive resource for omics research on drugs”. Nucleic Acids Res. 39 (Database issue): D1035—41. PMID 21059682.
^ Wishart DS, Knox C, Guo AC, Cheng D, Shrivastava S, Tzur D, Gautam B, Hassanali M (Nucleic Acids Res) (2008). „DrugBank: a knowledgebase for drugs, drug actions and drug targets”. 36 (Database issue): D901—6. PMID 18048412.

Spoljašnje veze

Suxamethonium chloride

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[1] Jonsson M, Dabrowski M, Gurley DA, Larsson O, Johnson EC, Fredholm BB, Eriksson LI: Activation and inhibition of human muscular and neuronal nicotinic acetylcholine receptors by succinylcholine. Anesthesiology. 2006 Apr;104(4):724-33. PMID 16571968

[2] Knox C, Law V, Jewison T, Liu P, Ly S, Frolkis A, Pon A, Banco K, Mak C, Neveu V, Djoumbou Y, Eisner R, Guo AC, Wishart DS (2011). „DrugBank 3.0: a comprehensive resource for omics research on drugs”. Nucleic Acids Res. 39 (Database issue): D1035—41. PMID 21059682.

[3] Wishart DS, Knox C, Guo AC, Cheng D, Shrivastava S, Tzur D, Gautam B, Hassanali M (Nucleic Acids Res) (2008). „DrugBank: a knowledgebase for drugs, drug actions and drug targets”. 36 (Database issue): D901—6. PMID 18048412.

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