Tentoksilizin
| Tentoksilizin | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 3.4.24.68 | ||||||||
| CAS broj | 107231-12-9 | ||||||||
| Baze podataka | |||||||||
| IntEnz | IntEnz pregled | ||||||||
| BRENDA | BRENDA pristup | ||||||||
| ExPASy | NiceZyme pregled | ||||||||
| KEGG | KEGG pristup | ||||||||
| MetaCyc | metabolički put | ||||||||
| PRIAM | profil | ||||||||
| Strukture PBP | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
Tentoksilizin (EC 3.4.24.68, tetanus neurotoksin) je enzim.[1][2][3][4][5] Ovaj enzim katalizuje sledeću hemijsku reakciju
- Hidroliza -Gln76-Phe- veze u sinaptobrevinu
Ovaj cinkov enzim proizvodi Clostridium tetani.
Reference
[уреди | уреди извор]- ^ Fujii, N., Kimura, K., Yashiki, T., Tsuzuki, K., Moriishi, K., Yokosawa, N., Syuto, B. and Oguma, K. (1992). „A zinc-protease specific domain in botulinum and tetanus neurotoxins”. Microbiol. Intern. 36: 213—220. PMID 1376283.
- ^ Schiavo, G., Benfenati, F., Poulain, B., Rossetto, O., Polverino de Laureto, P., DasGupta, B.R. and Montecucco, C. (1992). „Tetanus and botulinum-B neurotoxins block neurotransmitter release by proteolytic cleavage of synaptobrevin”. Nature. 359: 832—834. PMID 1331807.
- ^ Schiavo, G., Rossetto, O., Santucci, A., DasGupta, B.R. and Montecucco, C. (1992). „Botulinum neurotoxins are zinc proteins”. J. Biol. Chem. 267: 23479—23483. PMID 1429690.
- ^ Montecucco, C. & Schiavo, G. (1994). „Mechanism of action of tetanus and botulinum neurotoxins”. Mol. Microbiol. 8: 1—13. PMID 7527117.
- ^ Schiavo, G. & Montecucco, C. (1995). „Tetanus and botulism neurotoxins”. Methods Enzymol. 248: 643—652. PMID 7674951.
Literatura
[уреди | уреди извор]- Nicholas C. Price; Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third изд.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 изд.). Wiley-Interscience. ISBN 0471205036.
- Branden C; Tooze J. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 изд.). Wiley Classics Library. ISBN 0471303097.
- William P. Jencks (1987). Catalysis in Chemistry and Enzymology. Dover Publications. ISBN 0486654605.
Spoljašnje veze
[уреди | уреди извор]- Tentoxilysin на US National Library of Medicine Medical Subject Headings (MeSH)
