Timetna oligopeptidaza
| Timetna oligopeptidaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 3.4.24.15 | ||||||||
| CAS broj | 110639-28-6 | ||||||||
| Baze podataka | |||||||||
| IntEnz | IntEnz pregled | ||||||||
| BRENDA | BRENDA pristup | ||||||||
| ExPASy | NiceZyme pregled | ||||||||
| KEGG | KEGG pristup | ||||||||
| MetaCyc | metabolički put | ||||||||
| PRIAM | profil | ||||||||
| Strukture PBP | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
Timetna oligopeptidaza (EC 3.4.24.15, Pz-peptidaza, rastvorna metaloendopeptidaza, endo-oligopeptidaza A, tkivna endopeptidaza) je enzim.[1][2][3][4][5] Ovaj enzim katalizuje sledeću hemijsku reakciju
- Preferentno razlaganje veza sa hidrofobnim ostatacima na P1, P2 i P3', kao i malih ostataka u P1' u supstratima sa 5-15 ostataka
Ovo tiolno jedinjenje se aktivira pri niskim koncentracijama.
Reference
[уреди | уреди извор]- ^ Cicilini, M.A., Ribeiro, M.J.F., de Oliveira, E.B., Mortara, R.A. and de Camargo, A.C.M. (1988). „Endooligopeptidase A activity in rabbit heart: generation of enkephalin from enkephalin containing peptides”. Peptides (Fayetteville). 9: 945—955. PMID 3244563.
- ^ Orlowski, M., Reznik, S., Ayala, J. and Pierotti, A.R. (1989). „Endopeptidase 24.15 from rat testes. Isolation of the enzyme and its specificity toward synthetic and natural peptides, including enkephalin-containing peptides”. Biochem. J. 261: 951—958. PMID 2803255.
- ^ Barrett, A.J. & Brown, M.A. (1990). „Chicken liver Pz-peptidase, a thiol-dependent metallo-endopeptidase”. Biochem. J. 271: 701—706. PMID 2123097.
- ^ Pierotti, A., Dong, K.W., Glucksman, M.J., Orlowski, M. and Roberts, J.L. (1990). „Molecular cloning and primary structure of rat testes metalloendopeptidase EC 3.4.24.15”. Biochemistry. 29: 10323—10329. PMID 2261476.
- ^ Tisljar, U. & Barrett, A.J. (1990). „Thiol-dependent metallo-endopeptidase characteristics of Pz-peptidase in rat and rabbit”. Biochem. J. 267: 531—533. PMID 2185743.
Literatura
[уреди | уреди извор]- Nicholas C. Price; Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third изд.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 изд.). Wiley-Interscience. ISBN 0471205036.
- Branden C; Tooze J. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 изд.). Wiley Classics Library. ISBN 0471303097.
Spoljašnje veze
[уреди | уреди извор]- Thimet+oligopeptidase на US National Library of Medicine Medical Subject Headings (MeSH)
