Sfingomijelinska deacilaza
| Sfingomijelinska deacilaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 3.5.1.109 | ||||||||
| Baze podataka | |||||||||
| IntEnz | IntEnz pregled | ||||||||
| BRENDA | BRENDA pristup | ||||||||
| ExPASy | NiceZyme pregled | ||||||||
| KEGG | KEGG pristup | ||||||||
| MetaCyc | metabolički put | ||||||||
| PRIAM | profil | ||||||||
| Strukture PBP | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
Sfingomijelinska deacilaza (EC 3.5.1.109, SM deacilaza, GcSM deacilaza, glukozilkeramid sfingomijelinska deacilaza, sfingomijelin glukozilkeramidna deacilaza, SM glukozilkeramid GCer deacilaza, SM-GCer deacilaza, SMGCer deacilaza) je enzim sa sistematskim imenom N-acil-sfingozilfosforilholin amidohidrolaza.[1][2][3] Ovaj enzim katalizuje sledeću hemijsku reakciju
- (1) N-acil-sfingozilfosforilholin + H2O masna kiselina + sfingozilfosforilholin;;
- (2) D-glukozil-N-acilsfingozin + H2O masna kiselina + D-glukozil-sfingozin
Ovaj enzim učestvuje u sfingolipidnom metabolizmu u epidermisu.
Reference
[uredi | uredi izvor]- ^ Hara, J., Higuchi, K., Okamoto, R., Kawashima, M. and Imokawa, G. (2000). „High-expression of sphingomyelin deacylase is an important determinant of ceramide deficiency leading to barrier disruption in atopic dermatitis”. J. Invest. Dermatol. 115: 406—413. PMID 10951276.
- ^ Higuchi, K., Hara, J., Okamoto, R., Kawashima, M. and Imokawa, G. (2000). „The skin of atopic dermatitis patients contains a novel enzyme, glucosylceramide sphingomyelin deacylase, which cleaves the N-acyl linkage of sphingomyelin and glucosylceramide”. Biochem. J. 350: 747—756. PMID 10970788.
- ^ Ishibashi, M., Arikawa, J., Okamoto, R., Kawashima, M., Takagi, Y., Ohguchi, K. and Imokawa, G. (2003). „Abnormal expression of the novel epidermal enzyme, glucosylceramide deacylase, and the accumulation of its enzymatic reaction product, glucosylsphingosine, in the skin of patients with atopic dermatitis”. Lab. Invest. 83: 397—408. PMID 12649340.
Literatura
[uredi | uredi izvor]- Nicholas C. Price; Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C; Tooze J. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
Spoljašnje veze
[uredi | uredi izvor]- Sphingomyelin+deacylase na US National Library of Medicine Medical Subject Headings (MeSH)
