Fosforibozilaminoimidazolsukcinokarboksamidna sintaza
| Fosforibozilaminoimidazolsukcinokarboksamidna sintaza | |||||||||
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| Identifikatori | |||||||||
| EC broj | 6.3.2.6 | ||||||||
| CAS broj | 9023-67-0 | ||||||||
| Baze podataka | |||||||||
| IntEnz | IntEnz pregled | ||||||||
| BRENDA | BRENDA pristup | ||||||||
| ExPASy | NiceZyme pregled | ||||||||
| KEGG | KEGG pristup | ||||||||
| MetaCyc | metabolički put | ||||||||
| PRIAM | profil | ||||||||
| Strukture PBP | RCSB PDB PDBe PDBj PDBsum | ||||||||
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Fosforibozilaminoimidazolsukcinokarboksamidna sintaza (EC 6.3.2.6, fosforibozilaminoimidazol-sukcinokarboksamidna sintetaza, PurC, SAICAR sintetaza, 4-(N-sukcinokarboksamid)-5-aminoimidazolna sintetaza, 4-((N-sukcinilamino)karbonil)-5-aminoimidazol ribonukleotidna sintetaza, SAICARs, fosforibozilaminoimidazolsukcinokarboksamidna sintetaza, 5-aminoimidazol-4-N-sukcinokarboksamid ribonukleotid sintetaza) je enzim sa sistematskim imenom 5-amino-1-(5-fosfo-D-ribozil)imidazol-4-karboksilat:L-aspartat ligaza (formira ADP).[1][2][3][4][5][6] Ovaj enzim katalizuje sledeću hemijsku reakciju
- ATP + 5-amino-1-(5-fosfo-D-ribozil)imidazol-4-karboksilat + L-aspartat ADP + fosfat + (S)-2-[5-amino-1-(5-fosfo-D-ribozil)imidazole-4-karboksamido]sukcinat
Ovaj enzim učestvuje u purinskoj biosintezi.
Reference
[уреди | уреди извор]- ^ Lukens, L.N. & Buchanan, J.M. (1959). „Biosynthesis of purines. XXIV. The enzymatic synthesis of 5-amino-1-ribosyl-4-imidazolecarboxylic acid 5′-phosphate from 5-amino-1-ribosylimidazole 5′-phosphate and carbon dioxide”. J. Biol. Chem. 234: 1799—1805. PMID 13672967.
- ^ Parker, J. (1984). „Identification of the purC gene product of Escherichia coli”. J. Bacteriol. 157: 712—717. PMID 6365889.
- ^ Ebbole, D.J. & Zalkin, H. (1987). „Cloning and characterization of a 12-gene cluster from Bacillus subtilis encoding nine enzymes for de novo purine nucleotide synthesis”. J. Biol. Chem. 262: 8274—8287. PMID 3036807.
- ^ Chen, Z.D., Dixon, J.E. and Zalkin, H. (1990). „Cloning of a chicken liver cDNA encoding 5-aminoimidazole ribonucleotide carboxylase and 5-aminoimidazole-4-N-succinocarboxamide ribonucleotide synthetase by functional complementation of Escherichia coli pur mutants”. Proc. Natl. Acad. Sci. USA. 87: 3097—3101. PMID 1691501.
- ^ O'Donnell, A.F., Tiong, S., Nash, D. and Clark, D.V. (2000). „The Drosophila melanogaster ade5 gene encodes a bifunctional enzyme for two steps in the de novo purine synthesis pathway”. Genetics. 154: 1239—1253. PMID 10757766.
- ^ Nelson, S.W., Binkowski, D.J., Honzatko, R.B. and Fromm, H.J. (2005). „Mechanism of action of Escherichia coli phosphoribosylaminoimidazolesuccinocarboxamide synthetase”. Biochemistry. 44: 766—774. PMID 15641804.
Literatura
[уреди | уреди извор]- Nicholas C. Price; Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third изд.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 изд.). Wiley-Interscience. ISBN 0471205036.
- Branden C; Tooze J. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 изд.). Wiley Classics Library. ISBN 0471303097.
- William P. Jencks (1987). Catalysis in Chemistry and Enzymology. Dover Publications. ISBN 0486654605.
Spoljašnje veze
[уреди | уреди извор]- Phosphoribosylaminoimidazolesuccinocarboxamide+synthase на US National Library of Medicine Medical Subject Headings (MeSH)
