HDAC7A
HDAC7A, histonska deacetilaza 7 je enzim koji je kod čoveka kodiran HDAC7 genom.[1][2][3]
Histoni imaju kritičnu ulogu u transkripcionoj regulaciji, progresu ćelijskog ciklusa, i razvojnim stupnjevima. Histonska acetilacija/deacetilacija menja strukturu hromozoma i uslovljava pristup transkripcionih faktora do DNK. Protein kodiran ovim genom je sekventno homologan sa članovima familije histon deacetilaza. Ovaj gen je ortologan sa HDAC7 genom miša, čiji protein promoviše represiju posredovanu transkripcionim korepresorom SMRT. Multiple alternativno splajsovane transkriptne varijante koje kodiraju nekoliko izoformi su nađene.[3]
Interakcije
[уреди | уреди извор]Za HDAC7A je bilo pokazano da interaguje sa endotelinskim receptorom tipa A,[4] HDAC3,[5] HTATIP,[6] BCL6,[7] nuklearnim receptorskim korepresorom 1[5] i IKZF1.[8]
Vidi još
[уреди | уреди извор]Literatura
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- ^ а б „Entrez Gene: HDAC7A histone deacetylase 7A”.
- ^ Lee, H J; Chun M; Kandror K V (2001). „Tip60 and HDAC7 interact with the endothelin receptor a and may be involved in downstream signaling”. J. Biol. Chem. United States. 276 (20): 16597—600. ISSN 0021-9258. PMID 11262386. doi:10.1074/jbc.C000909200.
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- ^ Xiao, Hui; Chung Jin; et al. (2003). „Tip60 is a co-repressor for STAT3”. J. Biol. Chem. United States. 278 (13): 11197—204. ISSN 0021-9258. PMID 12551922. doi:10.1074/jbc.M210816200.
- ^ Lemercier, Claudie; Brocard Marie-Paule; et al. (2002). „Class II histone deacetylases are directly recruited by BCL6 transcriptional repressor”. J. Biol. Chem. United States. 277 (24): 22045—52. ISSN 0021-9258. PMID 11929873. doi:10.1074/jbc.M201736200.
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Dodatna literatura
[уреди | уреди извор]- Verdin E, Dequiedt F, Kasler HG (2003). „Class II histone deacetylases: versatile regulators.”. Trends Genet. 19 (5): 286—93. PMID 12711221. doi:10.1016/S0168-9525(03)00073-8.
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- Lee HJ, Chun M, Kandror KV (2001). „Tip60 and HDAC7 interact with the endothelin receptor a and may be involved in downstream signaling”. J. Biol. Chem. 276 (20): 16597—600. PMID 11262386. doi:10.1074/jbc.C000909200.
- Fischle W; Dequiedt F; Fillion M; et al. (2001). „Human HDAC7 histone deacetylase activity is associated with HDAC3 in vivo”. J. Biol. Chem. 276 (38): 35826—35. PMID 11466315. doi:10.1074/jbc.M104935200.
- Lemercier C; Brocard MP; Puvion-Dutilleul F; et al. (2002). „Class II histone deacetylases are directly recruited by BCL6 transcriptional repressor”. J. Biol. Chem. 277 (24): 22045—52. PMID 11929873. doi:10.1074/jbc.M201736200.
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- Strausberg RL; Feingold EA; Grouse LH; et al. (2003). „Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences”. Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899—903. PMC 139241 . PMID 12477932. doi:10.1073/pnas.242603899.
- Xiao H, Chung J, Kao HY, Yang YC (2003). „Tip60 is a co-repressor for STAT3”. J. Biol. Chem. 278 (13): 11197—204. PMID 12551922. doi:10.1074/jbc.M210816200.
- Dequiedt F; Kasler H; Fischle W; et al. (2003). „HDAC7, a thymus-specific class II histone deacetylase, regulates Nur77 transcription and TCR-mediated apoptosis”. Immunity. 18 (5): 687—98. PMID 12753745. doi:10.1016/S1074-7613(03)00109-2.
- Lee CH; Chawla A; Urbiztondo N; et al. (2003). „Transcriptional repression of atherogenic inflammation: modulation by PPARdelta”. Science. 302 (5644): 453—7. PMID 12970571. doi:10.1126/science.1087344.
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- Li X; Song S; Liu Y; et al. (2004). „Phosphorylation of the histone deacetylase 7 modulates its stability and association with 14-3-3 proteins”. J. Biol. Chem. 279 (33): 34201—8. PMID 15166223. doi:10.1074/jbc.M405179200.
- Kato H, Tamamizu-Kato S, Shibasaki F (2004). „Histone deacetylase 7 associates with hypoxia-inducible factor 1alpha and increases transcriptional activity”. J. Biol. Chem. 279 (40): 41966—74. PMID 15280364. doi:10.1074/jbc.M406320200.
- Beausoleil SA; Jedrychowski M; Schwartz D; et al. (2004). „Large-scale characterization of HeLa cell nuclear phosphoproteins”. Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130—5. PMC 514446 . PMID 15302935. doi:10.1073/pnas.0404720101.
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Spoljašnje veze
[уреди | уреди извор]- HDAC7A+protein,+human на US National Library of Medicine Medical Subject Headings (MeSH)
