Levonantradol
 | |
| IUPAC ime | |
|---|---|
[(6S,6aR,9R,10aR)- 9-hidroksi- 6-metil- 3-[(2R)-5-fenilpentan- 2-il]oksi- 5,6,6a,7,8,9,10,10a-oktahidrofenantridin- 1-il] acetat | |
| Identifikatori | |
| CAS broj | 71048-87-8  |
| ATC kod | none |
| PubChem | CID 5361881 |
| ChemSpider | 4514867 |
| UNII | 03S640ADSK |
| Hemijski podaci | |
| Formula | C27H35NO4 |
| Molarna masa | 437,571 g/mol |
| |
| |
Levonantradol (CP 50,556-1) je sintetički kanabinoidni analog dronabinola (Marinola). Ovaj lek je razvila kompanija Pfizer tokom 1980-tih. On je oko 30x puta potentniji od THC, i manifestuje antiemetske i analgetske efekte putem aktivacije CB1 i CB2 kanabinoidnih receptora.[1] Levonantradol trenutno nije u upotrebi jer su dronabinol i nabilon primenljivi na veći broj oboljenja. On nalazi široku primenu u istraživanju potencijalne terapeutske primene kanabinoida.[2][3][4]
Vidi još
[уреди | уреди извор]Reference
[уреди | уреди извор]- ^ Little PJ, et al. Pharmacology and stereoselectivity of structurally novel cannabinoids in mice. Journal of Pharmacology and Experimental Therapeutics 1988; 247:1046–1051.
- ^ Tramer MR, et al. Cannabinoids for control of chemotherapy induced nausea and vomiting: quantitative systematic review. British Medical Journal 2001 Jul 7;323(7303):16-21.
- ^ Campbell FA, et al. Are cannabinoids an effective and safe treatment option in the management of pain? A qualitative systematic review. British Medical Journal. 2001 Jul 7;323(7303):13-6.
- ^ Ben Amar M. Cannabinoids in medicine: A review of their therapeutic potential. Journal of Ethnopharmacology. 2006 Apr 21;105(1-2):1-25.
Literatura
[уреди | уреди извор]- Childers, SR (2006-03-10). „Activation of G-proteins in brain by endogenous and exogenous cannabinoids.”. The AAPS journal. 8 (1): E112—7. PMC 2751429
. PMID 16584117. doi:10.1208/aapsj080113. - Hosking, R.D.; Zajicek, J.P. (2008). „Therapeutic potential of cannabis in pain medicine”. British Journal of Anaesthesia. 101 (1): 59—68.
- McCarthy, LE; Borison, HL (1981). „Antiemetic activity of N-methyllevonantradol and nabilone in cisplatin-treated cats.”. Journal of clinical pharmacology. 21 (8–9 Suppl): 30S—37S. PMID 6271834.
- Milewich, L; Gant, NF; et al. (1979-03-15). „5 alpha-Reductase activity in human placenta.”. American journal of obstetrics and gynecology. 133 (6): 611—7. PMID 34324.
