Формат-тетрахидрофолатна лигаза
| Format-tetrahidrofolatna ligaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
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| Identifikatori | |||||||||
| EC broj | 6.3.4.3 | ||||||||
| CAS broj | 9023-66-9 | ||||||||
| Baze podataka | |||||||||
| IntEnz | IntEnz pregled | ||||||||
| BRENDA | BRENDA pristup | ||||||||
| ExPASy | NiceZyme pregled | ||||||||
| KEGG | KEGG pristup | ||||||||
| MetaCyc | metabolički put | ||||||||
| PRIAM | profil | ||||||||
| Strukture PBP | RCSB PDB PDBe PDBj PDBsum | ||||||||
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Format-tetrahidrofolatna ligaza (EC 6.3.4.3, formiltetrahidrofolatna sintetaza, 10-formiltetrahidrofolatna sintetaza, tetrahidrofolna formilaza, tetrahidrofolatna formilaza) je enzim sa sistematskim imenom format:tetrahidrofolat ligaza (formira ADP).[1][2][3][4] Ovaj enzim katalizuje sledeću hemijsku reakciju
- ATP + format + tetrahidrofolat ADP + fosfat + 10-formiltetrahidrofolat
Kod eukariota se javlja trifunkcionalni enzim.
Reference
[уреди | уреди извор]- ^ Jaenicke, L. & Brode, E. (1961). „Untersuchungen über Einkohlenstoffkörper. I. Die Tetrahydrofolatformylase aus Taubenleber. Rinigung und Mechanismus”. Biochem. Z. 334: 108—132. PMID 13789141.
- ^ Long, C.W., Levitzki, A., Houston, L.L and Koshland, D.E., Jr. (1969). „Subunit structures and interactions of CTP synthetase”. Fed. Proc. 28: 342—342.
- ^ Rabinowitz, J.C. & Pricer, W.E. (1962). „Formyltetrahydrofolate synthetase. I. Isolation and crystallization of the enzyme”. J. Biol. Chem. 237: 2898—2902. PMID 14489619.
- ^ Whiteley, H.R., Osborn, M.J. and Huennekens, F.M. (1959). „Purification and properties of the formate-activating enzyme from Micrococcus aerogenes”. J. Biol. Chem. 234: 1538—1543. PMID 13654413.
Literatura
[уреди | уреди извор]- Nicholas C. Price; Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third изд.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 изд.). Wiley-Interscience. ISBN 0471205036.
- Branden C; Tooze J. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 изд.). Wiley Classics Library. ISBN 0471303097.
- William P. Jencks (1987). Catalysis in Chemistry and Enzymology. Dover Publications. ISBN 0486654605.
Spoljašnje veze
[уреди | уреди извор]- Formate---tetrahydrofolate+ligase на US National Library of Medicine Medical Subject Headings (MeSH)
