JTE-907
 | |
| IUPAC ime | |
|---|---|
N-(benzo[1,3]dioksol-5-ilmetil)-7-metoksi-2-okso-8-pentiloksi-1,2-dihidrohinolin-3-karboksamid | |
| Identifikatori | |
| CAS broj | 282089-49-0  |
| ATC kod | none |
| PubChem | CID 9867770 |
| Hemijski podaci | |
| Formula | C24H26N2O6 |
| Molarna masa | 438,472 |
| |
JTE-907 je lek koji se koristi u naučnim istraživanjima. On deluje kao selektivni inverzni agonist CB2 receptora.[1][2] On ima antiinflamatorno dejstvo u životinjskim studijama.[3] Smatra se da posreduje interakciju između CB2 receptora u IgE.[4]
Референце
[uredi | uredi izvor]- ^ Iwamura, H; Suzuki, H; Ueda, Y; Kaya, T; Inaba, T (2001). „In vitro and in vivo pharmacological characterization of JTE-907, a novel selective ligand for cannabinoid CB2 receptor”. The Journal of Pharmacology and Experimental Therapeutics. 296 (2): 420—5. PMID 11160626.
- ^ Raitio, KH; Savinainen, JR; Vepsäläinen, J; Laitinen, JT; Poso, A; Järvinen, T; Nevalainen, T (2006). „Synthesis and SAR studies of 2-oxoquinoline derivatives as CB2 receptor inverse agonists”. Journal of Medical Chemistry. 49 (6): 2022—7. PMID 16539390. doi:10.1021/jm050879z.
- ^ Ueda, Y; Miyagawa, N; Matsui, T; Kaya, T; Iwamura, H (2005). „Involvement of cannabinoid CB(2) receptor-mediated response and efficacy of cannabinoid CB(2) receptor inverse agonist, JTE-907, in cutaneous inflammation in mice”. European Journal of Pharmacology. 520 (1–3): 164—71. PMID 16153638. doi:10.1016/j.ejphar.2005.08.013.
- ^ Ueda, Y; Miyagawa, N; Wakitani, K (2007). „Involvement of cannabinoid CB2 receptors in the IgE-mediated triphasic cutaneous reaction in mice”. Life Sciences. 80 (5): 414—9. PMID 17055000. doi:10.1016/j.lfs.2006.09.026.
