Kinurenin
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| Nazivi | |
|---|---|
| IUPAC naziv
(S)-2-Amino-4-(2-aminophenyl)- 4-oxo-butanoic acid
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| Drugi nazivi
(S)-Kinurenin
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| Identifikacija | |
3D model (Jmol)
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| MeSH | Kynurenine |
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| Svojstva | |
| C10H12N2O3 | |
| Molarna masa | 208,22 g·mol−1 |
Ukoliko nije drugačije napomenuto, podaci se odnose na standardno stanje materijala (na 25 °C [77 °F], 100 kPa). | |
| Reference infokutije | |
L-Kinurenin je metabolit aminokiseline L-triptofan[3] koji se koristi u produkciji niacina. Smatra se da posreduje pojavu tikova.[4][5]
Kinureninaza katabolizuje konverziju kinurenina u antranilnu kiselinu[6], dok kinurenin—oksoglutarat transaminaza katabolizuje njegovu konverziju u kinurensku kiselinu. Kinurenin 3-hidroksilaza konvertuje kinurenin do 3-hidroksikinurenina.[7]
Reference
[уреди | уреди извор]- ^ Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today. 15 (23-24): 1052—7. PMID 20970519. doi:10.1016/j.drudis.2010.10.003.
- ^ Evan E. Bolton; Yanli Wang; Paul A. Thiessen; Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry. 4: 217—241. doi:10.1016/S1574-1400(08)00012-1.
- ^ Moroni F (1999). „Tryptophan metabolism and brain function: focus on kynurenine and other indole metabolites”. European Journal of Pharmacology. 375 (1-3): 87—100. PMID 10443567.
- ^ Hoekstra PJ, Anderson GM, Troost PW, Kallenberg CG, Minderaa RB (2007). „Plasma kynurenine and related measures in tic disorder patients”. European Child & Adolescent Psychiatry. 16 Suppl 1: 71—7. PMID 17665285. doi:10.1007/s00787-007-1009-1.
- ^ „Kynurenine potentiates the DOI head shake in mice | DeepDyve - Research. Rent. Read.”. Архивирано из оригинала 21. 07. 2011. г. Приступљено 06. 04. 2011.
- ^ European Bioinformatics Institute. „Kynureninase,”.
- ^ Saito, Y., Hayaishi, O., Rothberg, S. (1957). „Studies on oxygenases; enzymatic formation of 3-hydroxy-L-kynurenine from L-kynurenine”. J. Biol. Chem. 229 (2): 921–34. PMID 13502353.
