Amtamin

Amtamin
Nazivi
	IUPAC naziv 5-(2-aminoetil)-4-metil-1,3-tiazol-2-amin
	Drugi nazivi 5-(2-aminoetil)-4-metil-2-tiazolamin; 2-amino-5-(2-aminoetil)-4-metilthiazol
Identifikacija
CAS broj	142437-67-0;
3D model (Jmol)	interaktivna slika; interaktivna slika;
ChemSpider	112538 ;
PubChem C ID	126688;
	SMILES CC1=C(SC(=N1)N)CCN; n1c(c(sc1N)CCN)C; ; ; ; ;
Svojstva
Hemijska formula	C6H11N3S
Molarna masa	157,236 g/mol
	Ukoliko nije drugačije napomenuto, podaci se odnose na standardno stanje materijala (na 25 °C [77 °F], 100 kPa).
	verifikuj (šta je ?)
	Reference infokutije

Amtamin je histaminski agonist koji je selektivan za H₂ receptor.^[3] On je korišten u in vitro i in vivo ispitivanjima gastričke sekrecije,^[4] kao i drugih funkcija H₂ receptora.^[5]^[6]^[7]

Reference

^ Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today. 15 (23-24): 1052—7. PMID 20970519. doi:10.1016/j.drudis.2010.10.003. уреди
^ Evan E. Bolton; Yanli Wang; Paul A. Thiessen; Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry. 4: 217—241. doi:10.1016/S1574-1400(08)00012-1.
^ Eriks JC, van der Goot H, Sterk GJ, Timmerman H. Histamine H2-receptor agonists. Synthesis, in vitro pharmacology, and qualitative structure-activity relationships of substituted 4- and 5-(2-aminoethyl)thiazoles. Eriks, J. C.; Van Der Goot, H.; Sterk, G. J.; Timmerman, H. (1992 Aug 21). „Histamine H2-receptor agonists. Synthesis, in vitro pharmacology, and qualitative structure-activity relationships of substituted 4- and 5-(2-aminoethyl)thiazoles”. Journal of Medicinal Chemistry. 35 (17): 3239—46. PMID 1507209. doi:10.1021/jm00095a021. Проверите вредност парамет(а)ра за датум: |date= (помоћ)
^ Coruzzi G, Timmerman H, Adami M, Bertaccini G (1993). „The new potent and selective histamine H2 receptor agonist amthamine as a tool to study gastric secretion”. Naunyn Schmiedebergs Arch Pharmacol. 348 (1): 77—81. PMID 8377843. doi:10.1007/BF00168540.
^ Ezeamuzie CI, Philips E. Histamine H(2) receptors mediate the inhibitory effect of histamine on human eosinophil degranulation. Ezeamuzie, C. I.; Philips, E. (октобар 2000). „Histamine H(2) receptors mediate the inhibitory effect of histamine on human eosinophil degranulation”. British Journal of Pharmacology. 131 (3): 482—8. PMC 1572337 . PMID 11015298. doi:10.1038/sj.bjp.0703556.
^ Fernandez N, Monczor F, Baldi A, Davio C, Shayo C. Fernandez, N.; Monczor, F.; Baldi, A.; Davio, C.; Shayo, C. (октобар 2008). „Histamine H2 receptor trafficking: role of arrestin, dynamin, and clathrin in histamine H2 receptor internalization”. Molecular Pharmacology. 74 (4): 1109—18. PMID 18617631. doi:10.1124/mol.108.045336. hdl:11336/25894.
^ Threlfell S, Exley R, Cragg SJ, Greenfield SA. Threlfell, S.; Exley, R.; Cragg, S. J.; Greenfield, S. A. (новембар 2008). „Constitutive histamine H2 receptor activity regulates serotonin release in the substantia nigra”. Journal of Neurochemistry. 107 (3): 745—55. PMID 18761715. doi:10.1111/j.1471-4159.2008.05646.x.

Spoljašnje veze

[1] Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today. 15 (23-24): 1052—7. PMID 20970519. doi:10.1016/j.drudis.2010.10.003. уреди

[2] Evan E. Bolton; Yanli Wang; Paul A. Thiessen; Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry. 4: 217—241. doi:10.1016/S1574-1400(08)00012-1.

[3] Eriks JC, van der Goot H, Sterk GJ, Timmerman H. Histamine H2-receptor agonists. Synthesis, in vitro pharmacology, and qualitative structure-activity relationships of substituted 4- and 5-(2-aminoethyl)thiazoles. Eriks, J. C.; Van Der Goot, H.; Sterk, G. J.; Timmerman, H. (1992 Aug 21). „Histamine H2-receptor agonists. Synthesis, in vitro pharmacology, and qualitative structure-activity relationships of substituted 4- and 5-(2-aminoethyl)thiazoles”. Journal of Medicinal Chemistry. 35 (17): 3239—46. PMID 1507209. doi:10.1021/jm00095a021. Проверите вредност парамет(а)ра за датум: |date= (помоћ)

[4] Coruzzi G, Timmerman H, Adami M, Bertaccini G (1993). „The new potent and selective histamine H2 receptor agonist amthamine as a tool to study gastric secretion”. Naunyn Schmiedebergs Arch Pharmacol. 348 (1): 77—81. PMID 8377843. doi:10.1007/BF00168540.

[5] Ezeamuzie CI, Philips E. Histamine H(2) receptors mediate the inhibitory effect of histamine on human eosinophil degranulation. Ezeamuzie, C. I.; Philips, E. (октобар 2000). „Histamine H(2) receptors mediate the inhibitory effect of histamine on human eosinophil degranulation”. British Journal of Pharmacology. 131 (3): 482—8. PMC 1572337 . PMID 11015298. doi:10.1038/sj.bjp.0703556.

[6] Fernandez N, Monczor F, Baldi A, Davio C, Shayo C. Fernandez, N.; Monczor, F.; Baldi, A.; Davio, C.; Shayo, C. (октобар 2008). „Histamine H2 receptor trafficking: role of arrestin, dynamin, and clathrin in histamine H2 receptor internalization”. Molecular Pharmacology. 74 (4): 1109—18. PMID 18617631. doi:10.1124/mol.108.045336. hdl:11336/25894.

[7] Threlfell S, Exley R, Cragg SJ, Greenfield SA. Threlfell, S.; Exley, R.; Cragg, S. J.; Greenfield, S. A. (новембар 2008). „Constitutive histamine H2 receptor activity regulates serotonin release in the substantia nigra”. Journal of Neurochemistry. 107 (3): 745—55. PMID 18761715. doi:10.1111/j.1471-4159.2008.05646.x.

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