Histaminski H1 receptor
Изглед
H1 receptor je histaminski receptor iz familije rodopsinu sličnih G protein spregnutih receptora. Ovaj receptor, koji aktivira biogeni amin histamin, je izražen širom tela, u glatkim mišićima, vaskularnim endotelnim ćelijama, u srcu, i u centralnom nervnom sistemu. H1 receptor je spregnut sa intracelularnim G proteinom (Gq) koji aktivira signalni put fosfolipaze C i fosfatidilinozitola (PIP2). Antihistamini koji deluju na ovaj receptor se koriste kao lekovi protiv alergije. Kristalna struktura receptora je određena.[1]
Reference
[уреди | уреди извор]- ^ Tatsuro Shimamura, Mitsunori Shiroishi, Simone Weyand, Hirokazu Tsujimoto, Graeme Winter, Vsevolod Katritch, Ruben Abagyan, Vadim Cherezov, Wei Liu, Gye Won Han, Takuya Kobayashi, Raymond C. Stevens & So Iwata (2011). „Structure of the human histamine H1 receptor complex with doxepin”. Nature. 475 (7354): 65—70. PMID 21697825. doi:10.1038/nature10236.
Literatura
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Vidi još
[уреди | уреди извор]- Antihistaminik – antagonist H1 receptora
Spoljašnje veze
[уреди | уреди извор]- „Histamine Receptors: H1”. IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. Архивирано из оригинала 03. 03. 2016. г.