Bradikininski receptor B₂

Bradikininski receptor B2
Bradikininski receptor B2
Identifikatori
Simboli	BDKRB2; B2R; BK-2; BK2; BKR2; BRB2; DKFZp686O088
Vanjski ID	OMIM: 113503 MGI: 102845 HomoloGene: 519 IUPHAR: B2 GeneCards: BDKRB2 Gene
Ontologija gena
Molekularna funkcija	• rodopsinu-slična receptorska aktivnost; • aktivnost fosfoinozitid fosfolipaze C; • receptorska aktivnost; • aktivnost bradikininskog receptora;
Celularna komponenta	• ćelijska membrana; • integralno sa ćelijskom membranom;
Biološki proces	• kontrakcija glatkih mišića; • inflamatorni respons; • signalni put tirozinske kinaze; • signalni put G-protein spregnutog receptora; • elevacija citosolne koncentracije jona kalcijuma; • senzorna percepcija; • cirkulacija;
Pregled RNK izražavanja
	podaci
Ortolozi
Vrsta	Čovek
Entrez	624
Ensembl	ENSG00000168398
UniProt	P30411
RefSeq (mRNA)	NM_000623
RefSeq (protein)	NP_000614
Lokacija (UCSC)	Chr 14:; 95.74 - 95.78 Mb
PubMed pretraga	[1]

Bradikininski receptor B₂ je G-protein spregnuti receptor bradikinina. Njega kodira BDKRB2 gen kod čoveka.

Mehanizam

B₂ receptor je G protein-spregnuti receptor. Pretpostavlja se da je spregnut sa G_q, dok G_i. G_q stimuliše fosfolipazu C i povišava koncentraciju Intracelularnog slobodnog kalcijuma i G_i inhibira adenilat ciklazu. Pored toga, receptor stimuliše puteve mitogenom-aktiviranih proteinskih kinaza. On je široko rasprostranjen i konstitutivno izražen u zdravim tkivima.

B₂ receptor formira kompleks sa angiotenzin konvertujućim enzimom (ACE), i stoga se smatra da učestvuje u razmeni informacija između renin-angiotenzinskog sistema (RAS) i kinin-kalikreinskog sistema (KKS). Heptapeptid angiotenzin 1-7 (A1-7) takođe pojačava dejstvo bradikinina na B₂ receptore.^[1]

Kalidin takođe dejstvuje kroz B₂ receptor.

Funkcija

Bradikinin je peptid sa 9 aminokiselina koji proizvodi mnogobrojne response kao što su vazodilatacija, edemi i spazam glatkih mišića.

Vidi još

Bradikininski receptor

Literatura

^ Fernandes L, Fortes ZB, Nigro D, Tostes RC, Santos RA, Catelli De Carvalho MH (2001). „Potentiation of bradykinin by angiotensin-(1-7) on arterioles of spontaneously hypertensive rats studied in vivo”. Hypertension. 37 (2 Part 2): 703—9. PMID 11230360. Архивирано из оригинала 28. 05. 2008. г. Приступљено 29. 01. 2011.

Dodatna literatura

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Eggerickx D; Raspe E; Bertrand D; et al. (1992). „Molecular cloning, functional expression and pharmacological characterization of a human bradykinin B2 receptor gene.”. Biochem. Biophys. Res. Commun. 187 (3): 1306—13. PMID 1329734. doi:10.1016/0006-291X(92)90445-Q.
Kammerer S, Braun A, Arnold N, Roscher AA (1995). „The human bradykinin B2 receptor gene: full length cDNA, genomic organization and identification of the regulatory region.”. Biochem. Biophys. Res. Commun. 211 (1): 226—33. PMID 7779089. doi:10.1006/bbrc.1995.1800.
Braun A; Kammerer S; Böhme E; et al. (1995). „Identification of polymorphic sites of the human bradykinin B2 receptor gene.”. Biochem. Biophys. Res. Commun. 211 (1): 234—40. PMID 7779090. doi:10.1006/bbrc.1995.1801.
Ma JX; Wang DZ; Ward DC; et al. (1995). „Structure and chromosomal localization of the gene (BDKRB2) encoding human bradykinin B2 receptor.”. Genomics. 23 (2): 362—9. PMID 7835885. doi:10.1006/geno.1994.1512.
Powell SJ; Slynn G; Thomas C; et al. (1993). „Human bradykinin B2 receptor: nucleotide sequence analysis and assignment to chromosome 14.”. Genomics. 15 (2): 435—8. PMID 7916737. doi:10.1006/geno.1993.1084.
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Hess JF; Borkowski JA; Macneil T; et al. (1994). „Differential pharmacology of cloned human and mouse B2 bradykinin receptors.”. Mol. Pharmacol. 45 (1): 1—8. PMID 8302267.
McIntyre P; Phillips E; Skidmore E; et al. (1993). „Cloned murine bradykinin receptor exhibits a mixed B1 and B2 pharmacological selectivity.”. Mol. Pharmacol. 44 (2): 346—55. PMID 8394991.
AbdAlla S; Godovac-Zimmermann J; Braun A; et al. (1996). „Structure of the bradykinin B2 receptors' amino terminus.”. Biochemistry. 35 (23): 7514—9. PMID 8652530. doi:10.1021/bi9601060.
Isami S; Kishikawa H; Araki E; et al. (1996). „Bradykinin enhances GLUT4 translocation through the increase of insulin receptor tyrosine kinase in primary adipocytes: evidence that bradykinin stimulates the insulin signalling pathway.”. Diabetologia. 39 (4): 412—20. PMID 8777990. doi:10.1007/BF00400672.
Dalemar LR, Ivy Jong YJ, Wilhelm B, Baenziger NL (1996). „Protein kinases A and C rapidly modulate expression of human lung fibroblast B2 bradykinin receptor affinity forms.”. Eur. J. Cell Biol. 69 (3): 236—44. PMID 8900488.
Soskic V; Nyakatura E; Roos M; et al. (1999). „Correlations in palmitoylation and multiple phosphorylation of rat bradykinin B2 receptor in Chinese hamster ovary cells.”. J. Biol. Chem. 274 (13): 8539—45. PMID 10085087. doi:10.1074/jbc.274.13.8539.
Cassano G, Susca F, Lippe C, Guanti G (1999). „Two B1 and B2 bradykinin receptor antagonists fail to inhibit the Ca2+ response elicited by bradykinin in human skin fibroblasts.”. Gen. Pharmacol. 32 (2): 239—44. PMID 10188626. doi:10.1016/S0306-3623(98)00275-4.
Efremov R; Truong MJ; Darcissac EC; et al. (1999). „Human chemokine receptors CCR5, CCR3 and CCR2B share common polarity motif in the first extracellular loop with other human G-protein coupled receptors implications for HIV-1 coreceptor function.”. Eur. J. Biochem. 263 (3): 746—56. PMID 10469138. doi:10.1046/j.1432-1327.1999.00553.x.
Marrero MB; Venema VJ; Ju H; et al. (1999). „Endothelial nitric oxide synthase interactions with G-protein-coupled receptors.”. Biochem. J. 343 Pt 2: 335—40. PMC 1220558 . PMID 10510297. doi:10.1042/0264-6021:3430335.
Reyes-Cruz G, Vázquez-Prado J, Müller-Esterl W, Vaca L (2000). „Regulation of the human bradykinin B2 receptor expressed in sf21 insect cells: a possible role for tyrosine kinases.”. J. Cell. Biochem. 76 (4): 658—73. PMID 10653985. doi:10.1002/(SICI)1097-4644(20000315)76:4<658::AID-JCB14>3.0.CO;2-7.
Golser R; Gorren AC; Leber A; et al. (2000). „Interaction of endothelial and neuronal nitric-oxide synthases with the bradykinin B2 receptor. Binding of an inhibitory peptide to the oxygenase domain blocks uncoupled NADPH oxidation.”. J. Biol. Chem. 275 (8): 5291—6. PMID 10681501. doi:10.1074/jbc.275.8.5291.

[pmid11230360-1] Fernandes L, Fortes ZB, Nigro D, Tostes RC, Santos RA, Catelli De Carvalho MH (2001). „Potentiation of bradykinin by angiotensin-(1-7) on arterioles of spontaneously hypertensive rats studied in vivo”. Hypertension. 37 (2 Part 2): 703—9. PMID 11230360. Архивирано из оригинала 28. 05. 2008. г. Приступљено 29. 01. 2011.

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