Receptor slobodnih masnih kiselina — Википедија

Receptor slobodnih masnih kiselina 1
Identifikatori
Simbol	FFAR1, FFA1R
Alt. simboli	GPR40
Entrez	2864
HUGO	4498
OMIM	603820
RefSeq	NM_005303
UniProt	O14842
Ostali podaci
Lokus	Hromozom 19 q13.1

Receptor slobodnih masnih kiselina 2
Identifikatori
Simbol	FFAR2
Alt. simboli	GPR43, FFA2R
Entrez	2867
HUGO	4501
OMIM	603823
RefSeq	NM_005306
UniProt	O15552
Ostali podaci
Lokus	Hromozom 19 q13.1

Receptor slobodnih masnih kiselina 3
Identifikatori
Simbol	FFAR3
Alt. simboli	GPR41, FFA3R
Entrez	2865
HUGO	4499
OMIM	603821
RefSeq	NM_005304
UniProt	O14843
Ostali podaci
Lokus	Hromozom 19 q13.1

G protein-spregnuti receptor 42
Identifikatori
Simbol	GPR42
Alt. simboli	GPR41L, FFAR1L
Entrez	2866
HUGO	4500
OMIM	603822
RefSeq	NM_005305
UniProt	O15529
Ostali podaci
Lokus	Hromozom 19 q31.1

Receptor slobodnih masnih kiselina je G-protein spregnuti receptor vezuje slobodne masne kiseline.^[1] Postoje četiri varijante ovog receptora, koje su kodirane zasebnim genima (FFAR1, FFAR2, FFAR3, GPR42)^[2].

Референце

^ Covington DK, Briscoe CA, Brown AJ, Jayawickreme CK (2006). „The G-protein-coupled receptor 40 family (GPR40-GPR43) and its role in nutrient sensing”. Biochem. Soc. Trans. 34 (Pt 5): 770—3. PMID 17052194. doi:10.1042/BST0340770.
^ R. Lee Kennedy, Venkat Vangaveti, Ghassan Jarrod, Venkatesh Shashidhar, Venkatesh Shashidhar, Bernhard T. Baune (2010). „Review: Free fatty acid receptors: emerging targets for treatment of diabetes and its complications”. Therapeutic Advances in Endocrinology and Metabolism October. SAGE. 1 (4): 165—175. doi:10.1177/2042018810381066. Архивирано из оригинала 28. 10. 2014. г. Приступљено 06. 03. 2011.

„Free Fatty Acid Receptors”. IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. Архивирано из оригинала 03. 03. 2016. г.
FFAR1+protein,+human на US National Library of Medicine Medical Subject Headings (MeSH)
G-protein+coupled+receptor+43,+human на US National Library of Medicine Medical Subject Headings (MeSH)
FFAR3+protein,+human на US National Library of Medicine Medical Subject Headings (MeSH)

Adrenergički	α1 (A, B, D) • α2 (A, B, C) • β1 • β2 • β3
Purinski	Adenozinski (A1, A2A, A2B, A3) • P2Y (1, 2, 4, 5, 6, 8, 9, 10, 11, 12, 13, 14)
Serotoninski	(svi osim 5-HT3) 5-HT1 (A, B, D, E, F) • 5-HT2 (A, B, C) • 5-HT (4, 5A, 6, 7)
Drugi	Acetilholin (M1, M2, M3, M4, M5) • Dopamin (D1, D2, D3, D4, D5) • Histamin (H1, H2, H3, H4) • Melatonin (1A, 1B, 1C) • TAAR (1, 2, 3, 5, 6, 8, 9)

Metaboliti i
signalni molekuli

Eikozanoidni	CysLT (1, 2) • LTB4 (1, 2) • FPRL1 • OXE • Prostaglandin (DP (1, 2), EP (1, 2, 3, 4), FP) • Prostaciklin • Tromboksan
Drugi	Žučna kiselina • Kanabinoidni (CB1, CB2, GPR (18, 55, 119)) • EBI2 • Estrogen • Slobodna masna kiselina (1, 2, 3, 4) • Laktat • Lizofosfatidna kiselina (1, 2, 3, 4, 5, 6) • Lizofosfolipid (1, 2, 3, 4, 5, 6, 7, 8) • Niacin (1, 2) • Oksoglutarat • PAF • Sfingozin-1-fosfat (1, 2, 3, 4, 5) • Sukcinat

Peptid

B/W (1, 2) • FF (1, 2) • S • Y (1, 2, 4, 5) • Neuromedin (B, U (1, 2)) • Neurotenzin (1, 2)

Drugi

Razno

Orfan	GPR (1, 3, 4, 6, 12, 15, 17, 18, 19, 20, 21, 22, 23, 25, 26, 27, 31, 32, 33, 34, 35, 37, 39, 42, 44, 45, 50, 52, 55, 61, 62, 63, 65, 68, 75, 77, 78, 81, 82, 83, 84, 85, 87, 88, 92, 101, 103, 109A, 109B, 119, 120, 132, 135, 137B, 139, 141, 142, 146, 148, 149, 150, 151, 152, 153, 160, 161, 162, 171, 173, 174, 176, 177, 182, 183)
Drugi	Adrenomedulin • Mirisni • Opsin (3, 4, 5, 1LW, 1MW, 1SW, RGR, RRH) • Proteazom-aktivirani (1, 2, 3, 4) • SREB (1, 2, 3)

Orfan	GPR (56, 64, 97, 98, 110, 111, 112, 113, 114, 115, 116, 123, 124, 125, 126, 128, 133, 143, 144, 155, 157)
Drugi	Moždano specifični angiogenezni inhibitor (1, 2, 3) • Kadherin (1, 2, 3) • Kalcitonin • CALCRL • CD97 • Kortikotropin-oslobađajući hormon (1, 2) • EMR (1, 2, 3) • Glukagon (GR, GIPR, GLP1R, GLP2R) • Hormon rasta • PACAPR1 • GPR • Latrofilin (1, 2, 3, ELTD1) • Metuzalemski protein • Paratiroidni hormon (1, 2) • Sekretin • Vazoaktivni intestinalni peptid (1, 2)

Ukus	TAS1R (1, 2, 3) • TAS2R (1, 3, 4, 5, 8, 9, 10, 12, 13, 14, 16, 19, 20, 30, 31, 38, 39, 40, 41, 42, 43, 45, 46, 50)
Drugi	Kalcijum-detektujući receptor • GABA B (1, 2) • Glutamatni receptor (Metabotropni glutamat (1, 2, 3, 4, 5, 6, 7, 8)) • GPRC6A • GPR (156, 158, 179) • RAIG (1, 2, 3, 4) • VNR (1, 2, 3, 5)

Uvojiti	Frizzled (1, 2, 3, 4, 5, 6, 7, 8, 9, 10)
Zaglađeni	Zaglađeni