OPN1LW
| Opsin 1, senzitivan na dugačke talasne dužine | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||||
| Simboli | OPN1LW; CBP; CBBM; RCP | ||||||||||
| Vanjski ID | OMIM: 303900 MGI: 1097692 HomoloGene: 68064 GeneCards: OPN1LW Gene | ||||||||||
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| Pregled RNK izražavanja | |||||||||||
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| podaci | |||||||||||
| Ortolozi | |||||||||||
| Vrsta | Čovek | Miš | |||||||||
| Entrez | 5956 | 14539 | |||||||||
| Ensembl | ENSG00000102076 | ENSMUSG00000031394 | |||||||||
| UniProt | P04000 | O35599 | |||||||||
| RefSeq (mRNA) | NM_020061 | NM_008106 | |||||||||
| RefSeq (protein) | NP_064445 | NP_032132 | |||||||||
| Lokacija (UCSC) |
Chr X: 153.06 - 153.08 Mb |
Chr X: 70.38 - 70.4 Mb | |||||||||
| PubMed pretraga | [1] | [2] | |||||||||
OPN1LW, crveno-senzitivni opsin, je protein koji je kod ljudi kodiran OPN1LW genom.[1]
Ovaj gen kodira pigment iz familije opsina koji apsorbuje svetlost. On se naziva crveni fotopigment kupastih ćelija, ili opsin senzitivan na dugačke talasne dužine. Opsini su grupa G-protein spregnutih receptora sa sedam transmembranskih domena, ekstracelularnim N-terminusnim domenom, i citosolnim C-terminusom. Ovaj gen i opsinski geni srednjih-talasnih dužina su grupisani na X hromozomu. Česte neravnomerne rekombinacije i konverzije gena se mogu javiti između tih sekvenci. X hromozomi mogu da imaju spajanja gena opsina srednje i duge talasne dužine, ili višestruke kopije tih gena. Defekti ovog gena su uzrok parcijalne slepoće za boje.[1]
Vidi još
[уреди | уреди извор]Literatura
[уреди | уреди извор]Dodatna literatura
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- Nakayama TA, Zhang W, Cowan A, Kung M (1999). „Mutagenesis studies of human red opsin: trp-281 is essential for proper folding and protein-retinal interactions.”. Biochemistry. 37 (50): 17487—94. PMID 9860863. doi:10.1021/bi982077u.
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- Fitzgerald KA; Rowe DC; Barnes BJ; et al. (2003). „LPS-TLR4 signaling to IRF-3/7 and NF-kappaB involves the toll adapters TRAM and TRIF.”. J. Exp. Med. 198 (7): 1043—55. PMC 2194210 . PMID 14517278. doi:10.1084/jem.20031023.
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