Neuropeptidni B/W receptor 2
Изглед
Neuropeptidni B/W receptor 2 | |||||||||||
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Identifikatori | |||||||||||
Simboli | NPBWR2; GPR8 | ||||||||||
Vanjski ID | OMIM: 600731 HomoloGene: 48336 IUPHAR: NPBW2 GeneCards: NPBWR2 Gene | ||||||||||
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Pregled RNK izražavanja | |||||||||||
podaci | |||||||||||
Ortolozi | |||||||||||
Vrsta | Čovek | Miš | |||||||||
Entrez | 2832 | n/a | |||||||||
Ensembl | ENSG00000125522 | n/a | |||||||||
UniProt | P48146 | n/a | |||||||||
RefSeq (mRNA) | NM_005286 | n/a | |||||||||
RefSeq (protein) | NP_005277 | n/a | |||||||||
Lokacija (UCSC) |
Chr 20: 62.21 - 62.21 Mb | n/a | |||||||||
PubMed pretraga | [1] | n/a |
Neuropeptidni B/W receptor 2 (NPBW2) je humani protein kodiran NPBWR2 genom.[1]
Ovaj protein je integralni membranski protein i G protein-spregnuti receptor. Njegova sekvenca je slična GPR7 receptoru. On je strukturno sličan opioidnim i somatostatinskim receptorima. Ovaj protein vezuje neuropeptide B i W. Ovaj gen ne sadrži introne. Prvenstveno je izražen u frontalnom korteksu mozga.[1]
Vidi još
[уреди | уреди извор]Literatura
[уреди | уреди извор]Dodatna literatura
[уреди | уреди извор]- O'Dowd BF; Scheideler MA; Nguyen T; et al. (1995). „The cloning and chromosomal mapping of two novel human opioid-somatostatin-like receptor genes, GPR7 and GPR8, expressed in discrete areas of the brain.”. Genomics. 28 (1): 84—91. PMID 7590751. doi:10.1006/geno.1995.1109.
- Deloukas P; Matthews LH; Ashurst J; et al. (2002). „The DNA sequence and comparative analysis of human chromosome 20.”. Nature. 414 (6866): 865—71. PMID 11780052. doi:10.1038/414865a.
- Shimomura Y; Harada M; Goto M; et al. (2002). „Identification of neuropeptide W as the endogenous ligand for orphan G-protein-coupled receptors GPR7 and GPR8.”. J. Biol. Chem. 277 (39): 35826—32. PMID 12130646. doi:10.1074/jbc.M205337200.
- Brezillon S; Lannoy V; Franssen JD; et al. (2003). „Identification of natural ligands for the orphan G protein-coupled receptors GPR7 and GPR8.”. J. Biol. Chem. 278 (2): 776—83. PMID 12401809. doi:10.1074/jbc.M206396200.
- Strausberg RL; Feingold EA; Grouse LH; et al. (2003). „Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.”. Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899—903. PMC 139241 . PMID 12477932. doi:10.1073/pnas.242603899.
- Tanaka H; Yoshida T; Miyamoto N; et al. (2003). „Characterization of a family of endogenous neuropeptide ligands for the G protein-coupled receptors GPR7 and GPR8.”. Proc. Natl. Acad. Sci. U.S.A. 100 (10): 6251—6. PMC 156358 . PMID 12719537. doi:10.1073/pnas.0837789100.
- Mazzocchi G; Rebuffat P; Ziolkowska A; et al. (2005). „G protein receptors 7 and 8 are expressed in human adrenocortical cells, and their endogenous ligands neuropeptides B and w enhance cortisol secretion by activating adenylate cyclase- and phospholipase C-dependent signaling cascades.”. J. Clin. Endocrinol. Metab. 90 (6): 3466—71. PMID 15797961. doi:10.1210/jc.2004-2132.
Spoljašnje veze
[уреди | уреди извор]- „Neuropeptide B/W Receptors: NPBW2”. IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. Архивирано из оригинала 03. 03. 2016. г.