CX717
(preusmereno sa CX-717)
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| IUPAC ime | |
|---|---|
| Klinički podaci | |
| Način primene | oralno, IV |
| Identifikatori | |
| CAS broj | 867276-98-0  |
| ATC kod | None |
| PubChem | CID 3323368 |
| ChemSpider | 2570822 |
| UNII | 7I12YTA3QM |
| Hemijski podaci | |
| Formula | C11H11N3O3 |
| Molarna masa | 233,23 g·mol−1 |
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CX717 je ampakinsko jedinjenje koje je razvila kompanija Korteks farmaceutikals.[3] CX717 utiče na neurotransmiter glutamat. Ispitivanja su pokazala da ovaj lek poboljšava kognitivne funkcije i memoriju.[4]
Vidi još
[uredi | uredi izvor]Reference
[uredi | uredi izvor]- ^ Radin DP, Purcell R, Lippa AS (јануар 2018). „Oncolytic Properties of Ampakines In Vitro”. Anticancer Research. 38 (1): 265—269. PMID 29277782. doi:10.21873/anticanres.12217
.
- ^ Purcell R, Lynch G, Gall C, Johnson S, Sheng Z, Stephen MR, et al. (april 2018). „Brain Vacuolation Resulting From Administration of the Type II Ampakine CX717 Is An Artifact Related to Molecular Structure and Chemical Reaction With Tissue Fixative Agents”. Toxicological Sciences. 162 (2): 383—395. PMID 29253237. doi:10.1093/toxsci/kfx277 .
- ^ „Benzofurazan compounds for enhancing glutamatergic synaptic responses”. Arhivirano iz originala 05. 09. 2012. g. Pristupljeno 04. 04. 2008.
- ^ Hampson RE, España RA, Rogers GA, Porrino LJ, Deadwyler SA (2009). „Mechanisms underlying cognitive enhancement and reversal of cognitive deficits in nonhuman primates by the ampakine CX717”. Psychopharmacology. 202 (1-3): 355—69. PMID 18985324. doi:10.1007/s00213-008-1360-z.
Literatura
[uredi | uredi izvor]- Bast T, da Silva BM, Morris RG (2005). „Distinct contributions of hippocampal NMDA and AMPA receptors to encoding and retrieval of one-trial place memory”. J. Neurosci. 25 (25): 5845—56. PMID 15976073. doi:10.1523/JNEUROSCI.0698-05.2005.
- Arai AC, Kessler M, Rogers G, Lynch G (2000). „Effects of the potent ampakine CX614 on hippocampal and recombinant AMPA receptors: interactions with cyclothiazide and GYKI 52466”. Mol. Pharmacol. 58 (4): 802—13. PMID 10999951. Arhivirano iz originala 07. 03. 2005. g. Pristupljeno 29. 05. 2012.
- Porrino LJ, Daunais JB, Rogers GA, Hampson RE, Deadwyler SA (2005). „Facilitation of task performance and removal of the effects of sleep deprivation by an ampakine (CX717) in nonhuman primates”. PLoS Biol. 3 (9): e299. PMC 1188239 . PMID 16104830. doi:10.1371/journal.pbio.0030299.
- Cortex Pharmaceuticals press release
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