CX717
 | |
| IUPAC ime | |
|---|---|
| Klinički podaci | |
| Način primene | oralno, IV |
| Identifikatori | |
| CAS broj | 867276-98-0  |
| ATC kod | None |
| PubChem | CID 3323368 |
| ChemSpider | 2570822 |
| UNII | 7I12YTA3QM |
| Hemijski podaci | |
| Formula | C11H11N3O3 |
| Molarna masa | 233,23 g·mol−1 |
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| |
CX717 je ampakinsko jedinjenje koje je razvila kompanija Korteks farmaceutikals.[3] CX717 utiče na neurotransmiter glutamat. Ispitivanja su pokazala da ovaj lek poboljšava kognitivne funkcije i memoriju.[4]
Vidi još
[уреди | уреди извор]Reference
[уреди | уреди извор]- ^ Radin DP, Purcell R, Lippa AS (јануар 2018). „Oncolytic Properties of Ampakines In Vitro”. Anticancer Research. 38 (1): 265—269. PMID 29277782. doi:10.21873/anticanres.12217
.
- ^ Purcell R, Lynch G, Gall C, Johnson S, Sheng Z, Stephen MR, et al. (април 2018). „Brain Vacuolation Resulting From Administration of the Type II Ampakine CX717 Is An Artifact Related to Molecular Structure and Chemical Reaction With Tissue Fixative Agents”. Toxicological Sciences. 162 (2): 383—395. PMID 29253237. doi:10.1093/toxsci/kfx277 .
- ^ „Benzofurazan compounds for enhancing glutamatergic synaptic responses”. Архивирано из оригинала 05. 09. 2012. г. Приступљено 04. 04. 2008.
- ^ Hampson RE, España RA, Rogers GA, Porrino LJ, Deadwyler SA (2009). „Mechanisms underlying cognitive enhancement and reversal of cognitive deficits in nonhuman primates by the ampakine CX717”. Psychopharmacology. 202 (1-3): 355—69. PMID 18985324. doi:10.1007/s00213-008-1360-z.
Literatura
[уреди | уреди извор]- Bast T, da Silva BM, Morris RG (2005). „Distinct contributions of hippocampal NMDA and AMPA receptors to encoding and retrieval of one-trial place memory”. J. Neurosci. 25 (25): 5845—56. PMID 15976073. doi:10.1523/JNEUROSCI.0698-05.2005.
- Arai AC, Kessler M, Rogers G, Lynch G (2000). „Effects of the potent ampakine CX614 on hippocampal and recombinant AMPA receptors: interactions with cyclothiazide and GYKI 52466”. Mol. Pharmacol. 58 (4): 802—13. PMID 10999951. Архивирано из оригинала 07. 03. 2005. г. Приступљено 29. 05. 2012.
- Porrino LJ, Daunais JB, Rogers GA, Hampson RE, Deadwyler SA (2005). „Facilitation of task performance and removal of the effects of sleep deprivation by an ampakine (CX717) in nonhuman primates”. PLoS Biol. 3 (9): e299. PMC 1188239 . PMID 16104830. doi:10.1371/journal.pbio.0030299.
- Cortex Pharmaceuticals press release
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