4-Me-αMT

4-Me-αMT
IUPAC ime
	1-metil-2-(4-metil-1H-indol-3-il)-etilamin
Klinički podaci
Način primene	Oralno
Pravni status
Pravni status	Nije kontrolisan (ali može biti obuhvaćen Federalnim analognim zakonom u Sjedinjenim Državama i sličnim zakonima u drugim zemljama);
Identifikatori
CAS broj	3569-29-7
ATC kod	none
PubChem	CID 28806639
ChemSpider	25392939
UNII	QY99ES7YWD
Hemijski podaci
Formula	C12H16N2
Molarna masa	188,27 g·mol−1
	SMILES CC(N)Cc2c1c([nH]c2)cccc1C; ;
	InChI InChI=1S/C12H16N2/c1-8-4-3-5-11-12(8)10(7-14-11)6-9(2)13/h3-5,7,9,14H,6,13H2,1-2H3 ; Key:KEOYEGHPRBDSKD-UHFFFAOYSA-N ;

4-Metil-α-metiltriptamin (4-Me-αMT), takođe poznat kao 4,α-dimetiltriptamin (4,α-DMT), i MP-809, je lek koji pripada triptaminskoj klasi. On je istraživan kao antidepresant tokom ranih 1960-ih ali nije plasiran na tržište.^[1]^[2] 4-Me-αMT je organsko jedinjenje, koje sadrži 12 atoma ugljenika i ima molekulsku masu od 188,269 Da.

Osobine

Osobina	Vrednost
Broj akceptora vodonika	1
Broj donora vodonika	2
Broj rotacionih veza	2
Particioni koeficijent^[3] (ALogP)	2,4
Rastvorljivost^[4] (logS, log(mol/L))	-3,5
Polarna površina^[5] (PSA, Å²)	41,8

Vidi još

Reference

^ Azima H, Arthurs D, Silver A, Azima FJ (децембар 1962). „The effect of MP-809 in depressive states: a multi-blind study”. The American Journal of Psychiatry. 119 (6): 573—4. PMID 13965759. doi:10.1176/ajp.119.6.573.
^ Brodey JF, Steiner WG, Himwich HE (април 1963). „An electrographic study of psilocin and 4-methyl-alpha-methyl tryptamine (MP-809)”. The Journal of Pharmacology and Experimental Therapeutics. 140: 8—18. PMID 14015664.
^ Ghose, A.K.; Viswanadhan V.N. & Wendoloski, J.J. (1998). „Prediction of Hydrophobic (Lipophilic) Properties of Small Organic Molecules Using Fragment Methods: An Analysis of AlogP and CLogP Methods”. J. Phys. Chem. A. 102: 3762—3772. doi:10.1021/jp980230o.
^ Tetko IV, Tanchuk VY, Kasheva TN, Villa AE (2001). „Estimation of Aqueous Solubility of Chemical Compounds Using E-State Indices”. Chem Inf. Comput. Sci. 41: 1488—1493. PMID 11749573. doi:10.1021/ci000392t.
^ Ertl P.; Rohde B.; Selzer P. (2000). „Fast calculation of molecular polar surface area as a sum of fragment based contributions and its application to the prediction of drug transport properties”. J. Med. Chem. 43: 3714—3717. PMID 11020286. doi:10.1021/jm000942e.

Literatura

Hardman JG, Limbird LE, Gilman AG (2001). Goodman & Gilman's The Pharmacological Basis of Therapeutics (10. изд.). New York: McGraw-Hill. ISBN 0071354697. doi:10.1036/0071422803.
Thomas L. Lemke; David A. Williams, ур. (2007). Foye's Principles of Medicinal Chemistry (6. изд.). Baltimore: Lippincott Willams & Wilkins. ISBN 0781768799.

Spoljašnje veze

4-Me-αMT

[pmid13965759-1] Azima H, Arthurs D, Silver A, Azima FJ (децембар 1962). „The effect of MP-809 in depressive states: a multi-blind study”. The American Journal of Psychiatry. 119 (6): 573—4. PMID 13965759. doi:10.1176/ajp.119.6.573.

[2] Brodey JF, Steiner WG, Himwich HE (април 1963). „An electrographic study of psilocin and 4-methyl-alpha-methyl tryptamine (MP-809)”. The Journal of Pharmacology and Experimental Therapeutics. 140: 8—18. PMID 14015664.

[3] Ghose, A.K.; Viswanadhan V.N. & Wendoloski, J.J. (1998). „Prediction of Hydrophobic (Lipophilic) Properties of Small Organic Molecules Using Fragment Methods: An Analysis of AlogP and CLogP Methods”. J. Phys. Chem. A. 102: 3762—3772. doi:10.1021/jp980230o.

[4] Tetko IV, Tanchuk VY, Kasheva TN, Villa AE (2001). „Estimation of Aqueous Solubility of Chemical Compounds Using E-State Indices”. Chem Inf. Comput. Sci. 41: 1488—1493. PMID 11749573. doi:10.1021/ci000392t.

[5] Ertl P.; Rohde B.; Selzer P. (2000). „Fast calculation of molecular polar surface area as a sum of fragment based contributions and its application to the prediction of drug transport properties”. J. Med. Chem. 43: 3714—3717. PMID 11020286. doi:10.1021/jm000942e.

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