Oksaflozan
 | |
| IUPAC ime | |
|---|---|
4-propan-2-il-2-[3-(trifluorometil)fenil]morfolin | |
| Klinički podaci | |
| Način primene | Oralno |
| Pravni status | |
| Pravni status |
|
| Identifikatori | |
| CAS broj | 26629-86-7  |
| ATC kod | N06AX10 (WHO) |
| PubChem | CID 432824 |
| ChemSpider | 382782 |
| UNII | V4WLW77V5Q |
| KEGG | D07340 |
| Hemijski podaci | |
| Formula | C14H18F3NO |
| Molarna masa | 273,29 g/mol |
| |
Oksaflozan (Confliktan) je antidepresiv i anksiolitik koji je uveden u prodaju 1982. za tretmant depresije, ali je u međuvremenu izašao iz upotrebe.[1][2] On je prolek za N-dealkiloksaflozan, koji deluje kao neselektivni agonist serotoninskih receptora: 5-HT1A (pKi = 7,1), 5-HT2A (pKi = 6,0), i 5-HT2C (pKi = 7,5).[3] Oksaflozan potencijalno ima i antiholinergičko dejstvo pri visokim dozama.[4]
Reference
[уреди | уреди извор]- ^ Swiss Pharmaceutical Society (2000). Index Nominum 2000: International Drug Directory (Book with CD-ROM). Boca Raton: Medpharm Scientific Publishers. стр. 766. ISBN 978-3-88763-075-1.
- ^ Sittig 1988, стр. 1122.
- ^ Leysen DC (1999). „Selective 5-HT2C agonists as potential antidepressants”. IDrugs : the Investigational Drugs Journal. 2 (2): 109—20. PMID 16160946.
- ^ Dutertre JP, Barbier P, Suc AL, Jonville AP, Autret E (1992). „Oxaflozane overdose in a child”. Journal of Toxicology. Clinical Toxicology. 30 (1): 123—6. PMID 1542141.
Literatura
[уреди | уреди извор]- Sittig, Marshall (1988). Pharmaceutical manufacturing encyclopedia. Park Ridge, N.J., U.S.A: Noyes Publications. стр. 1756. ISBN 978-0-8155-1144-1.
- Swiss Pharmaceutical Society (2000). Index Nominum 2000: International Drug Directory (Book with CD-ROM). Boca Raton: Medpharm Scientific Publishers. стр. 1932. ISBN 978-3-88763-075-1.
- Rascol A, Maurel H, David J, Layani M (1974). „[Preliminary clinical results of a new non tricyclic antidepressive drug: oxaflozane]”. Thérapie (на језику: French). 29 (1): 95—9. PMID 4603757.
- Hache J, Duchene-Marullaz P, Streichenberger G (1974). „[Pharmacological profile of a new non tricyclic antidepressant: oxaflozane (1,766 Cerm)]”. Thérapie (на језику: French). 29 (1): 81—93. PMID 4849381.
- Constantin M, Pognat JF (1979). „Comparative study of oxaflozane urinary metabolism in man, the dog and the rat. Identification of the principal metabolites”. Arzneimittel-Forschung. 29 (1): 109—14. PMID 582104.
- Bertolino A, palermo M, Porro V (1985). „Oxaflozane, a new nontricyclic antidepressant in the treatment of anxiety-depressions syndromes.”. Acta Ther (11): 209—218.
- Aguglia E (1986). „On the therapetic value of axaflozane: Its application in the treatment of emotional disturbances of the anxious-depressive type accompanied by somatic manifestations.”. Acta Ther (12): 259—267.
