RS-102,221
 | |
| IUPAC ime | |
|---|---|
N5-[5-(2,4-diokso-1,3,8-triazaspiro[4.5]dec-8-il)pentanoil] -2,4-dimetoksifenil4-(trifluorometil)benzenesulfonamid | |
| Identifikatori | |
| CAS broj | 185376-97-0  |
| ATC kod | none |
| PubChem | CID 3693566 |
| IUPHAR/BPS | 187 |
| ChEMBL | CHEMBL88402 |
| Sinonimi | RS-102,221; 8-[5-(2,4-Dimetoksi-5-(4-trifluorometilfenilsulfnamido)fenil -5-oksopentil]-1,3,8-triazaspiro[4.5]dekan-2,4-dion |
| Hemijski podaci | |
| Formula | C27H33F3N4O7S |
| Molarna masa | 614,632 g/mol |
| |
RS-102,221 je lek koji je bio jedno od prvih otkrivenih jedinjenja koja deluju kao potentan i selektivan antagonist na serotoninskom 5-HT2C receptoru, sa selektivnošću od oko 100x u odnosu na blisko srodne 5-HT2A i 5-HT2B receptore.[1] On je pokazao anksiolitičke efekte u životinjskim studijama,[2] povećanje efektivnosti SSRI antidepresiva,[3] i ima kompleksne interakcije sa kokainom, tako što povećava neke i snižava druge efekte, što odražava ulogu 5-HT2C receptora i regulaciji dopaminske signalizacije u mozgu.[4][5][6][7]
Reference
[уреди | уреди извор]- ^ Bonhaus DW, Weinhardt KK, Taylor M, DeSouza A, McNeeley PM, Szczepanski K, Fontana DJ, Trinh J, Rocha CL, Dawson MW, Flippin LA, Eglen RM. RS-102221: a novel high affinity and selective, 5-HT2C receptor antagonist. Neuropharmacology. 1997 Apr-May;36(4-5):621-9. PMID 9225287
- ^ Kuznetsova EG, Amstislavskaya TG, Shefer EA, Popova NK. Effect of 5-HT2C receptor antagonist RS 102221 on mouse behavior. Bulletin of Experimental Biology and Medicine. 2006 Jul;142(1):76-9. PMID 17369908
- ^ Cremers TI, Giorgetti M, Bosker FJ, Hogg S, Arnt J, Mørk A, Honig G, Bøgesø KP, Westerink BH, den Boer H, Wikstrom HV, Tecott LH. Inactivation of 5-HT(2C) receptors potentiates consequences of serotonin reuptake blockade. Neuropsychopharmacology. 2004 Oct;29(10):1782-9. PMID 15138437
- ^ Filip M, Cunningham KA. Serotonin 5-HT(2C) receptors in nucleus accumbens regulate expression of the hyperlocomotive and discriminative stimulus effects of cocaine. Pharmacology, Biochemistry and Behaviour. 2002 Apr;71(4):745-56. PMID 11888566
- ^ Filip M, Cunningham KA. Hyperlocomotive and discriminative stimulus effects of cocaine are under the control of serotonin(2C) (5-HT(2C)) receptors in rat prefrontal cortex. Journal of Pharmacology and Experimental Therapeutics. 2003 Aug;306(2):734-43. PMID 12721337
- ^ Morita K, Hamamoto M, Arai S, Kitayama S, Irifune M, Kawahara M, Kihira K, Dohi T. Inhibition of serotonin transporters by cocaine and meprylcaine through 5-TH2C receptor stimulation facilitates their seizure activities. Brain Research. 2005 Sep 28;1057(1-2):153-60. PMID 16125150
- ^ Dremencov E, Weizmann Y, Kinor N, Gispan-Herman I, Yadid G. Modulation of dopamine transmission by 5HT2C and 5HT3 receptors: a role in the antidepressant response. Current Drug Targets. 2006 Feb;7(2):165-75. PMID 16475958
