SB-215,505
 | |
| IUPAC ime | |
|---|---|
6-hloro-5-metil-N-hinolin-4-il-2,3-dihidroindol-1-karboksamid | |
| Identifikatori | |
| CAS broj | 162100-15-4  |
| ATC kod | none |
| PubChem | CID 6603999 |
| ChEMBL | CHEMBL525998 |
| Hemijski podaci | |
| Formula | C19H16ClN3O |
| Molarna masa | 337,803 g/mol |
| |
SB-215,505 je lek koji deluje kao potentan i selektivan antagonist na serotoninskom 5-HT2B receptoru, sa dobrom selektivnošću u odnosu na srodne 5-HT2A i 5-HT2C receptore.[1] On se koristi u naučnim istraživanjima funkcije 5-HT2 familije receptora, a posebno za studiranje uloge 5-HT2B receptora radu srca,[2][3][4] i za razlikovanje 5-HT2B-posredovanih responsa od onih proizvedenih 5-HT2A ili 5-HT2C receptorom.[5][6][7]
Reference
[уреди | уреди извор]- ^ Kantor S, Jakus R, Balogh B, Benko A, Bagdy G (2004). „Increased wakefulness, motor activity and decreased theta activity after blockade of the 5-HT2B receptor by the subtype-selective antagonist SB-215505”. British Journal of Pharmacology. 142 (8): 1332—42. PMC 1575194
. PMID 15265808. doi:10.1038/sj.bjp.0705887.
- ^ Jaffré F, Callebert J, Sarre A, Etienne N, Nebigil CG, Launay JM, Maroteaux L, Monassier L (2004). „Involvement of the serotonin 5-HT2B receptor in cardiac hypertrophy linked to sympathetic stimulation: control of interleukin-6, interleukin-1beta, and tumor necrosis factor-alpha cytokine production by ventricular fibroblasts”. Circulation. 110 (8): 969—74. PMID 15302781. doi:10.1161/01.CIR.0000139856.20505.57.
- ^ Liang YJ, Lai LP, Wang BW, Juang SJ, Chang CM, Leu JG, Shyu KG (2006). „Mechanical stress enhances serotonin 2B receptor modulating brain natriuretic peptide through nuclear factor-kappaB in cardiomyocytes”. Cardiovascular Research. 72 (2): 303—12. PMID 16962085. doi:10.1016/j.cardiores.2006.08.003.
- ^ Monassier L, Laplante MA, Jaffré F, Bousquet P, Maroteaux L, de Champlain J (2008). „Serotonin 5-HT(2B) receptor blockade prevents reactive oxygen species-induced cardiac hypertrophy in mice”. Hypertension. 52 (2): 301—7. PMID 18591460. doi:10.1161/HYPERTENSIONAHA.107.105551.
- ^ Reavill C, Kettle A, Holland V, Riley G, Blackburn TP (1999). „Attenuation of haloperidol-induced catalepsy by a 5-HT2C receptor antagonist”. British Journal of Pharmacology. 126 (3): 572—4. PMC 1565856 . PMID 10188965. doi:10.1038/sj.bjp.0702350.
- ^ Fletcher PJ, Grottick AJ, Higgins GA (2002). „Differential effects of the 5-HT(2A) receptor antagonist M100907 and the 5-HT(2C) receptor antagonist SB242084 on cocaine-induced locomotor activity, cocaine self-administration and cocaine-induced reinstatement of responding”. Neuropsychopharmacology. 27 (4): 576—86. PMID 12377394. doi:10.1016/S0893-133X(02)00342-1.
- ^ Fletcher PJ, Tampakeras M, Sinyard J, Higgins GA (2007). „Opposing effects of 5-HT(2A) and 5-HT(2C) receptor antagonists in the rat and mouse on premature responding in the five-choice serial reaction time test”. Psychopharmacology. 195 (2): 223—34. PMID 17673981. doi:10.1007/s00213-007-0891-z.
