2-Metil-2-butanol

2-Metil-2-butanol
Ball-and-stick model of 2-methyl-2-butanol	Space-filling model of the 2-methyl-2-butanol
Nazivi
	Preferisani IUPAC naziv 2-Metil-2-butanol
	Sistemski IUPAC naziv 2-Metilbutan-2-ol
	Drugi nazivi terc-Amil alkohol Amylene hydrate Dimethylethylcarbinol tert-pentil alkohol
Identifikacija
CAS broj	75-85-4 ;
3D model (Jmol)	interaktivna slika;
Bajlštajn	1361351
ChemSpider	6165 ;
ECHA InfoCard	100.000.827
EC broj	200-908-9
KEGG	D02931 ;
MeSH	tert-amyl+alcohol
PubChem C ID	6405;
RTECS	SC0175000
UNII	69C393R11Z ;
UN broj	1105
	SMILES CCC(C)(C)O; ; ; ; ; ;
Svojstva
Hemijska formula	C5H12O
Molarna masa	88,15 g·mol−1
Agregatno stanje	Bezbojna tečnost
Miris	miris kamfora, peperminta
Gustina	805 mg cm−3
Tačka topljenja	−9 °C; 16 °F; 264 K
Rastvorljivost u vodi	120 g dm−3
log P	1,095
Napon pare	1,6 kPa (na 20°C)
Indeks refrakcije (nD)	1,405
Termohemija
Standardna molarna entropija So298	229,3 J K−1 mol−1
Std entalpija; formiranja (ΔfH⦵298)	−380,0–−379,0 kJ mol−1
Std entalpija; sagorevanja ΔcHo298	−3,3036–−3.3026 MJ mol−1
Opasnosti
Bezbednost prilikom rukovanja	hazard.com
GHS grafikoni
GHS signalna reč	Opasnost
GHS opis opasnosti	H225, H315, H332, H335
GHS mere predostrožnosti	P210, P261
EU klasifikacija (DSD)	F Xn
R-oznake	R11, R20, R37/38
S-oznake	(S2), S46
NFPA 704	3 1 0
Tačka paljenja	19 °C (66 °F; 292 K)
Tačka spontanog; paljenja	437 °C (819 °F; 710 K)
Eksplozivni limiti	9%
	Ukoliko nije drugačije napomenuto, podaci se odnose na standardno stanje materijala (na 25 °C [77 °F], 100 kPa).
	verifikuj (šta je ?)
	Reference infokutije

2-Metil-2-butanol (terc-amil alkohol, 2M2B, amilen hidrat) je jedan od izomera amil alkohola. On je čista, bezbojna tečnost sa jakim mirisom peperminta ili kamfora.^[5]^[6] Kod ljudi on ispoljava sedativno, hipnotičko, i antikonvulsivno dejstvo slično etanolu pri gutanju ili udisanju. Ranije je korišten u medicini za te svrhe.^[7] On je aktivan u dozama u opsegu od 2.000-4.000 mg, te je 20 puta potentniji od etanol.a^[8]^[9] Njegov hipnotički potencijal je između hloral hidrata i paraldehida.^[10] In humans, 2-methyl-2-butanol is metabolized primarily via gluconoridation and oxidation to 2,3-dihydroxy-2-methylbutane.^[11] Prekomerna doza proizvodi simptome slične alkoholnom trovanju.

Reference

^ ^а ^б ^в ^г ^д ^ђ „tert-amyl alcohol - Compound Summary”. PubChem Compound. USA: National Center for Biotechnology Information. 26. 3. 2005. Identification and Related Records. Приступљено 13. 12. 2011.
^ Joanne Wixon; Douglas Kell (2000). „Website Review: The Kyoto Encyclopedia of Genes and Genomes — KEGG”. Yeast. 17 (1): 48—55. doi:10.1002/(SICI)1097-0061(200004)17:1<48::AID-YEA2>3.0.CO;2-H.
^ Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today. 15 (23-24): 1052—7. PMID 20970519. doi:10.1016/j.drudis.2010.10.003. уреди
^ Evan E. Bolton; Yanli Wang; Paul A. Thiessen; Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry. 4: 217—241. doi:10.1016/S1574-1400(08)00012-1.
^ Coblentz, Virgil (1899). The Newer Remedies: A reference manual for physicians, pharmacists, and students (3rd изд.). Philadelphia: P. Blakiston's Son & Co. стр. 18. Пронађени су сувишни параметри: |at= и |pages= (помоћ)
^ H. C. Wood & R. M. Smith, ур. (1887). „Amylene hydrate - a new hypnotic”. Therapeutic Gazette - A monthly journal of physiological and clinical therapeutics. Detroit MI and Philadelpia PA: G. S. Davis. 3: 605—606.
^ Lewis, Robert A. (1998). Lewis' Dictionary of Toxicology. CRC Press. стр. 45. ISBN 978-1-56670-223-2.
^ Hans Brandenberger & Robert A. A. Maes, ур. (1997). Analytical Toxicology for Clinical, Forensic and Pharmaceutical Chemists. стр. 401. ISBN 978-3-11-010731-9.
^ D. W. Yandell; et al. (1888). „Amylene hydrate, a new hypnotic”. The American Practitioner and News. Lousville KY: John P. Morton & Co. 5: 88—89.
^ F. A. Castle & C. Rice (1888). „Amylene and amylene hydrate”. The American Druggist. 17 (3): 58—59.
^ Collins, A. S.; Sumner, S. C.; Borghoff, S. J.; Medinsky, M. A. (1999). „A physiological model for tert-amyl methyl ether and tert-amyl alcohol: Hypothesis testing of model structures”. Toxicological sciences : an official journal of the Society of Toxicology. 49 (1): 15—28. PMID 10367338. doi:10.1093/toxsci/49.1.15.

Literatura

Hans Brandenberger & Robert A. A. Maes, ур. (1997). Analytical Toxicology for Clinical, Forensic and Pharmaceutical Chemists. стр. 401. ISBN 978-3-11-010731-9.
Coblentz, Virgil (1899). The Newer Remedies: A reference manual for physicians, pharmacists, and students (3rd изд.). Philadelphia: P. Blakiston's Son & Co. стр. 18. Пронађени су сувишни параметри: |at= и |pages= (помоћ)
Lewis, Robert A. (1998). Lewis' Dictionary of Toxicology. CRC Press. стр. 45. ISBN 978-1-56670-223-2.

Vidi još

[PubChem-1] а ^б ^в ^г ^д ^ђ „tert-amyl alcohol - Compound Summary”. PubChem Compound. USA: National Center for Biotechnology Information. 26. 3. 2005. Identification and Related Records. Приступљено 13. 12. 2011.

[2] Joanne Wixon; Douglas Kell (2000). „Website Review: The Kyoto Encyclopedia of Genes and Genomes — KEGG”. Yeast. 17 (1): 48—55. doi:10.1002/(SICI)1097-0061(200004)17:1<48::AID-YEA2>3.0.CO;2-H.

[3] Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today. 15 (23-24): 1052—7. PMID 20970519. doi:10.1016/j.drudis.2010.10.003. уреди

[4] Evan E. Bolton; Yanli Wang; Paul A. Thiessen; Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry. 4: 217—241. doi:10.1016/S1574-1400(08)00012-1.

[5] Coblentz, Virgil (1899). The Newer Remedies: A reference manual for physicians, pharmacists, and students (3rd изд.). Philadelphia: P. Blakiston's Son & Co. стр. 18. Пронађени су сувишни параметри: |at= и |pages= (помоћ)

[6] H. C. Wood & R. M. Smith, ур. (1887). „Amylene hydrate - a new hypnotic”. Therapeutic Gazette - A monthly journal of physiological and clinical therapeutics. Detroit MI and Philadelpia PA: G. S. Davis. 3: 605—606.

[7] Lewis, Robert A. (1998). Lewis' Dictionary of Toxicology. CRC Press. стр. 45. ISBN 978-1-56670-223-2.

[8] Hans Brandenberger & Robert A. A. Maes, ур. (1997). Analytical Toxicology for Clinical, Forensic and Pharmaceutical Chemists. стр. 401. ISBN 978-3-11-010731-9.

[9] D. W. Yandell; et al. (1888). „Amylene hydrate, a new hypnotic”. The American Practitioner and News. Lousville KY: John P. Morton & Co. 5: 88—89.

[10] F. A. Castle & C. Rice (1888). „Amylene and amylene hydrate”. The American Druggist. 17 (3): 58—59.

[11] Collins, A. S.; Sumner, S. C.; Borghoff, S. J.; Medinsky, M. A. (1999). „A physiological model for tert-amyl methyl ether and tert-amyl alcohol: Hypothesis testing of model structures”. Toxicological sciences : an official journal of the Society of Toxicology. 49 (1): 15—28. PMID 10367338. doi:10.1093/toxsci/49.1.15.

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p r u Alkoholi
(0°)	Metanol
Primarni alkoholi (1°)	Etanol Propan-1-ol Butanol/Izobutanol 1-Pentanol 1-Heksanol 1-Heptanol Masni alkohol: 1-Oktanol (C 8) 1-Nonanol (C 9) 1-Dekanol (C 10) Undekanol (C 11) Dodekanol (C 12) 1-Tetradekanol (C 14) Cetil alkohol (C 16) Stearil alkohol (C 18) Arahidil alkohol (C 20) Dokozanol (C 22) Tetrakozanol (C 24) Heksakozanol (C 26) Oktanozol (C 28) Triakontanol (C 30) Polikozanol
Sekondarni alkoholi (2°)	Izopropil alkohol 2-Butanol 2-Heksanol Cikloheksanol
Tercijarni alkoholi (3°)	tert-Butanol 2-Metil-2-butanol