Melanokortinski 3 receptor
| Melanokortin 3 receptor | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||||
| Simboli | MC3R; MC3 | ||||||||||
| Vanjski ID | OMIM: 155540 MGI: 96929 HomoloGene: 7412 IUPHAR: MC3 GeneCards: MC3R Gene | ||||||||||
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| Pregled RNK izražavanja | |||||||||||
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| podaci | |||||||||||
| Ortolozi | |||||||||||
| Vrsta | Čovek | Miš | |||||||||
| Entrez | 4159 | 17201 | |||||||||
| Ensembl | ENSG00000124089 | ENSMUSG00000038537 | |||||||||
| UniProt | P41968 | Q3ZAT4 | |||||||||
| RefSeq (mRNA) | NM_019888 | NM_008561 | |||||||||
| RefSeq (protein) | NP_063941 | NP_032587 | |||||||||
| Lokacija (UCSC) |
Chr 20: 54.26 - 54.26 Mb |
Chr 2: 171.94 - 171.94 Mb | |||||||||
| PubMed pretraga | [1] | [2] | |||||||||
Melanokortin receptor 3 je protein koji je kod ljudi kodiran MC3R genom.[1][2]
MC3 je G-protein spregnuti receptor za melanocit-stimulišući hormon i adrenokortikotropski hormon koji je izražen u tkivima izvan adrenalnog korteksa i melanocita. MC3R gen je lociran u istom regionu kao i locus za benignu neonatalnu epilepsiju. Miševi koji su deficitarni u ovom genu imaju povišenu masu masnog tkiva uprkos umanjenog unosa hrane, što sugestira ulogu ovog genskog produkta u regulaciji energijske homeostaze.[2]
Vidi još
[uredi | uredi izvor]Literatura
[uredi | uredi izvor]Dodatna literatura
[uredi | uredi izvor]- Magenis RE; Smith L; Nadeau JH; et al. (1994). „Mapping of the ACTH, MSH, and neural (MC3 and MC4) melanocortin receptors in the mouse and human.”. Mamm. Genome. 5 (8): 503—8. PMID 7949735. doi:10.1007/BF00369320.
- Konda Y; Gantz I; DelValle J; et al. (1994). „Interaction of dual intracellular signaling pathways activated by the melanocortin-3 receptor.”. J. Biol. Chem. 269 (18): 13162—6. PMID 8175743.
- Gantz I; Tashiro T; Barcroft C; et al. (1994). „Localization of the genes encoding the melanocortin-2 (adrenocorticotropic hormone) and melanocortin-3 receptors to chromosomes 18p11.2 and 20q13.2-q13.3 by fluorescence in situ hybridization.”. Genomics. 18 (1): 166—7. PMID 8276410. doi:10.1006/geno.1993.1448.
- Yang YK; Ollmann MM; Wilson BD; et al. (1997). „Effects of recombinant agouti-signaling protein on melanocortin action.”. Mol. Endocrinol. 11 (3): 274—80. PMID 9058374. doi:10.1210/me.11.3.274.
- Tota MR; Smith TS; Mao C; et al. (1999). „Molecular interaction of Agouti protein and Agouti-related protein with human melanocortin receptors.”. Biochemistry. 38 (3): 897—904. PMID 9893984. doi:10.1021/bi9815602.
- McNulty JC; Thompson DA; Bolin KA; et al. (2002). „High-resolution NMR structure of the chemically-synthesized melanocortin receptor binding domain AGRP(87-132) of the agouti-related protein.”. Biochemistry. 40 (51): 15520—7. PMID 11747427. doi:10.1021/bi0117192.
- Deloukas P; Matthews LH; Ashurst J; et al. (2002). „The DNA sequence and comparative analysis of human chromosome 20.”. Nature. 414 (6866): 865—71. PMID 11780052. doi:10.1038/414865a.
- Lee YS, Poh LK, Loke KY (2002). „A novel melanocortin 3 receptor gene (MC3R) mutation associated with severe obesity.”. J. Clin. Endocrinol. Metab. 87 (3): 1423—6. PMID 11889220. doi:10.1210/jc.87.3.1423.
- Qian S; Chen H; Weingarth D; et al. (2002). „Neither agouti-related protein nor neuropeptide Y is critically required for the regulation of energy homeostasis in mice.”. Mol. Cell. Biol. 22 (14): 5027—35. PMC 139785
. PMID 12077332. doi:10.1128/MCB.22.14.5027-5035.2002. - Boucher N; Lanouette CM; Larose M; et al. (2003). „A +2138InsCAGACC polymorphism of the melanocortin receptor 3 gene is associated in human with fat level and partitioning in interaction with body corpulence.”. Mol. Med. 8 (3): 158—65. PMC 2039979 . PMID 12142547.
- Wong J; Love DR; Kyle C; et al. (2002). „Melanocortin-3 receptor gene variants in a Maori kindred with obesity and early onset type 2 diabetes.”. Diabetes Res. Clin. Pract. 58 (1): 61—71. PMID 12161058. doi:10.1016/S0168-8227(02)00126-2.
- Strausberg RL; Feingold EA; Grouse LH; et al. (2003). „Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.”. Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899—903. PMC 139241 . PMID 12477932. doi:10.1073/pnas.242603899.
- Rached M, Buronfosse A, Begeot M, Penhoat A (2004). „Inactivation and intracellular retention of the human I183N mutated melanocortin 3 receptor associated with obesity.”. Biochim. Biophys. Acta. 1689 (3): 229—34. PMID 15276649. doi:10.1016/j.bbadis.2004.03.009.
- Tao YX, Segaloff DL (2004). „Functional characterization of melanocortin-3 receptor variants identify a loss-of-function mutation involving an amino acid critical for G protein-coupled receptor activation.”. J. Clin. Endocrinol. Metab. 89 (8): 3936—42. PMID 15292330. doi:10.1210/jc.2004-0367.
- Lapinsh M; Veiksina S; Uhlén S; et al. (2005). „Proteochemometric mapping of the interaction of organic compounds with melanocortin receptor subtypes.”. Mol. Pharmacol. 67 (1): 50—9. PMID 15470082. doi:10.1124/mol.104.002857.
- Gerhard DS; Wagner L; Feingold EA; et al. (2004). „The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”. Genome Res. 14 (10B): 2121—7. PMC 528928 . PMID 15489334. doi:10.1101/gr.2596504.
- Mandrika I, Petrovska R, Wikberg J (2005). „Melanocortin receptors form constitutive homo- and heterodimers.”. Biochem. Biophys. Res. Commun. 326 (2): 349—54. PMID 15582585. doi:10.1016/j.bbrc.2004.11.036.
- de Krom M; de Rijke CE; Hendriks J; et al. (2006). „Mutation analysis of the agouti related protein promoter region and the melanocortin-3 receptor in anorexia nervosa patients.”. Psychiatr. Genet. 15 (4): 237. PMID 16314751. doi:10.1097/00041444-200512000-00003.
- Chen M; Aprahamian CJ; Celik A; et al. (2006). „Molecular characterization of human melanocortin-3 receptor ligand-receptor interaction.”. Biochemistry. 45 (4): 1128—37. PMID 16430209. doi:10.1021/bi0521792.
- „Melanocortin Receptors: MC3”. IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. Архивирано из оригинала 06. 02. 2016. г.
